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• W2236107788 abstract "The Cordyceps species has been a good source of compounds with anticancer and anti-inflammatory activities. Recently, we reported a novel compound (4-isopropyl-2,6-bis(1-phenylethyl)phenol, KTH-13) with anticancer activity isolated from Cordyceps bassiana and created several derivatives to increase its pharmacological activity. In this study, we tested one of the KTH-013 derivatives, 4-isopropyl-2,6-bis(1-phenylethyl)aniline 1 (KTH-13-AD1), with regard to anti-inflammatory activity under macrophage-mediated inflammatory conditions. KTH-13-AD1 clearly suppressed the production of nitric oxide (NO) and reactive oxygen species (ROS) in lipopolysaccharide (LPS) and sodium nitroprusside- (SNP-) treated macrophage-like cells (RAW264.7 cells). Similarly, this compound also reduced mRNA expression of inducible NO synthase (iNOS) and tumor necrosis factor- α (TNF- α ), as analyzed by RT-PCR and real-time PCR. Interestingly, KTH-13-AD1 strongly diminished NF- κ B-mediated luciferase activities and nuclear translocation of NF- κ B family proteins. In accordance, KTH-13-AD1 suppressed the upstream signaling pathway of NF- κ B activation, including I κ B α , IKK α / β , AKT, p85/PI3K, and Src in a time- and dose-dependent manner. The autophosphorylation of Src and NF- κ B observed during the overexpression of Src was also suppressed by KTH-13-AD1. These results strongly suggest that KTH-13-AD1 has strong anti-inflammatory features mediated by suppression of the Src/NF- κ B regulatory loop." @default.
• W2236107788 created "2016-06-24" @default.
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• W2236107788 date "2015-01-01" @default.
• W2236107788 modified "2023-09-27" @default.
• W2236107788 title "4-Isopropyl-2,6-bis(1-phenylethyl)aniline 1, an Analogue of KTH-13 Isolated from<i>Cordyceps bassiana</i>, Inhibits the NF-<i>κ</i>B-Mediated Inflammatory Response" @default.
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• W2236107788 doi "https://doi.org/10.1155/2015/143025" @default.
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