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• W2236150170 endingPage "153" @default.
• W2236150170 startingPage "121" @default.
• W2236150170 abstract "Growing tumor tissues develop a stressful microenvironment characterized by hypoxia and acidosis. Tumor cells can survive these stresses via induction of adaptive transcriptional changes mediated primarily by the hypoxia-inducible factor (HIF), and via stimulation of ion transport machinery maintaining normal intracellular pH. In addition, through these adaptive responses tumor cells acquire new features endowing them with selective advantage in migration, invasion, metastasis, and resistance to therapy. Carbonic anhydrase IX (CA IX), a highly active cancer-related carbonic anhydrase isoform, is linked to both hypoxia, as a direct transcriptional target of HIF, and acidosis, as a component of mechanisms that facilitate ion transport across the plasma membrane and thereby counteract the intracellular accumulation of acidic metabolic products. Expression pattern of CA IX in human tumors reflects the activation of the HIF pathway by physiologic hypoxia, genetic defects, and/or oncogenic events. Moreover, CA IX plays an active role not only in pH regulation but also in cell migration and invasion. Thus, it is often exploited and/or investigated as an intrinsic marker of hypoxia, a prognostic indicator, and a therapeutic target for antibodies or inhibitors of the enzyme activity. It is believed that these CA IX-targeted therapeutic approaches can mediate the selective killing of CA IX-positive cells or sensitize tumor cells to conventional treatment modalities. In addition, both CA IX-specific antibodies and CA IX-selective inhibitors can serve as imaging tools allowing for selection of patients potentially benefiting from CA IX-directed therapy. Recent advances in understanding CA IX regulation and functional involvement in tumor progression as well as development of CA IX-binding drugs provide novel opportunities for treatment of hypoxic tumors." @default.
• W2236150170 created "2016-06-24" @default.
• W2236150170 creator A5007128413 @default.
• W2236150170 creator A5035652477 @default.
• W2236150170 date "2013-11-09" @default.
• W2236150170 modified "2023-10-16" @default.
• W2236150170 title "Carbonic Anhydrase IX: From Biology to Therapy" @default.
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