FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2236157085> ?p ?o ?g. }

• W2236157085 endingPage "417" @default.
• W2236157085 startingPage "410" @default.
• W2236157085 abstract "<h3>Objective:</h3> To determine the motor-behavioral and neural correlates of putative functional common variants in the sodium-channel Na_V1.8 encoding gene (<i>SCN10A</i>) in vivo in patients with multiple sclerosis (MS). <h3>Methods:</h3> We recruited 161 patients with relapsing-onset MS and 94 demographically comparable healthy participants. All patients with MS underwent structural MRI and clinical examinations (Expanded Disability Status Scale [EDSS] and Multiple Sclerosis Functional Composite [MSFC]). Whole-brain voxel-wise and cerebellar volumetry were performed to assess differences in regional brain volumes between genotype groups. Resting-state fMRI was acquired from 62 patients with MS to evaluate differences in cerebellar functional connectivity. All participants were genotyped for 4 potentially functional <i>SCN10A</i> polymorphisms. <h3>Results:</h3> Two <i>SCN10A</i> polymorphisms in high linkage disequilibrium (<i>r</i>² = 0.95) showed significant association with MSFC performance in patients with MS (rs6795970: <i>p</i> = 6.2 × 10⁻⁴; rs6801957: <i>p</i> = 0.0025). Patients with MS with rs6795970^AA genotype performed significantly worse than rs6795970^G carriers in MSFC (<i>p</i> = 1.8 × 10⁻⁴) and all of its subscores. This association was independent of EDSS and cerebellar atrophy. Although the genotype groups showed no difference in regional brain volumes, rs6795970^AA carriers demonstrated significantly diminished cerebellar functional connectivity with the thalami and midbrain. No significant <i>SCN10A</i>–genotype effect was observed on MSFC performance in healthy participants. <h3>Conclusions:</h3> Our data suggest that <i>SCN10A</i> variation substantially influences functional status, including prominent effects on motor coordination in patients with MS. These findings were supported by the effects of this variant on a neural system important for motor coordination, namely cerebello-thalamic circuitry. Overall, our findings add to the emerging evidence that suggests that sodium channel Na_V1.8 could serve as a target for future drug-based interventions to treat cerebellar dysfunction in MS." @default.
• W2236157085 created "2016-06-24" @default.
• W2236157085 creator A5000640857 @default.
• W2236157085 creator A5006313920 @default.
• W2236157085 creator A5009973258 @default.
• W2236157085 creator A5016285763 @default.
• W2236157085 creator A5021788938 @default.
• W2236157085 creator A5022517520 @default.
• W2236157085 creator A5027080939 @default.
• W2236157085 creator A5029440927 @default.
• W2236157085 creator A5031075174 @default.
• W2236157085 creator A5037639974 @default.
• W2236157085 creator A5038077223 @default.
• W2236157085 creator A5044089791 @default.
• W2236157085 creator A5045413854 @default.
• W2236157085 creator A5065650624 @default.
• W2236157085 creator A5082357914 @default.
• W2236157085 creator A5088698596 @default.
• W2236157085 creator A5088992746 @default.
• W2236157085 creator A5091651650 @default.
• W2236157085 date "2016-01-06" @default.
• W2236157085 modified "2023-10-16" @default.
• W2236157085 title "Channelopathy-related<i>SCN10A</i>gene variants predict cerebellar dysfunction in multiple sclerosis" @default.
• W2236157085 cites W1498123445 @default.
• W2236157085 cites W1578423490 @default.
• W2236157085 cites W1891773028 @default.
• W2236157085 cites W1964113540 @default.
• W2236157085 cites W1965887065 @default.
• W2236157085 cites W1967775917 @default.
• W2236157085 cites W1976769820 @default.
• W2236157085 cites W2001696757 @default.
• W2236157085 cites W2007729962 @default.
• W2236157085 cites W2011243041 @default.
• W2236157085 cites W2028868938 @default.
• W2236157085 cites W2029669444 @default.
• W2236157085 cites W2041191461 @default.
• W2236157085 cites W2041325253 @default.
• W2236157085 cites W2049433094 @default.
• W2236157085 cites W2054662073 @default.
• W2236157085 cites W2058721478 @default.
• W2236157085 cites W2071587849 @default.
• W2236157085 cites W2078311582 @default.
• W2236157085 cites W2094738549 @default.
• W2236157085 cites W2103115907 @default.
• W2236157085 cites W2112165124 @default.
• W2236157085 cites W2117257456 @default.
• W2236157085 cites W2117619772 @default.
• W2236157085 cites W2119360061 @default.
• W2236157085 cites W2119848633 @default.
• W2236157085 cites W2122545833 @default.
• W2236157085 cites W2125281575 @default.
• W2236157085 cites W2129286611 @default.
• W2236157085 cites W2135200424 @default.
• W2236157085 cites W2136838610 @default.
• W2236157085 cites W2142577589 @default.
• W2236157085 cites W2150378783 @default.
• W2236157085 cites W2155514239 @default.
• W2236157085 cites W2196009297 @default.
• W2236157085 cites W40340874 @default.
• W2236157085 cites W4238782826 @default.
• W2236157085 cites W4241890711 @default.
• W2236157085 doi "https://doi.org/10.1212/wnl.0000000000002326" @default.
• W2236157085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4773947" @default.
• W2236157085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26740675" @default.
• W2236157085 hasPublicationYear "2016" @default.
• W2236157085 type Work @default.
• W2236157085 sameAs 2236157085 @default.
• W2236157085 citedByCount "21" @default.
• W2236157085 countsByYear W22361570852016 @default.
• W2236157085 countsByYear W22361570852017 @default.
• W2236157085 countsByYear W22361570852018 @default.
• W2236157085 countsByYear W22361570852019 @default.
• W2236157085 countsByYear W22361570852020 @default.
• W2236157085 countsByYear W22361570852021 @default.
• W2236157085 countsByYear W22361570852022 @default.
• W2236157085 countsByYear W22361570852023 @default.
• W2236157085 crossrefType "journal-article" @default.
• W2236157085 hasAuthorship W2236157085A5000640857 @default.
• W2236157085 hasAuthorship W2236157085A5006313920 @default.
• W2236157085 hasAuthorship W2236157085A5009973258 @default.
• W2236157085 hasAuthorship W2236157085A5016285763 @default.
• W2236157085 hasAuthorship W2236157085A5021788938 @default.
• W2236157085 hasAuthorship W2236157085A5022517520 @default.
• W2236157085 hasAuthorship W2236157085A5027080939 @default.
• W2236157085 hasAuthorship W2236157085A5029440927 @default.
• W2236157085 hasAuthorship W2236157085A5031075174 @default.
• W2236157085 hasAuthorship W2236157085A5037639974 @default.
• W2236157085 hasAuthorship W2236157085A5038077223 @default.
• W2236157085 hasAuthorship W2236157085A5044089791 @default.
• W2236157085 hasAuthorship W2236157085A5045413854 @default.
• W2236157085 hasAuthorship W2236157085A5065650624 @default.
• W2236157085 hasAuthorship W2236157085A5082357914 @default.
• W2236157085 hasAuthorship W2236157085A5088698596 @default.
• W2236157085 hasAuthorship W2236157085A5088992746 @default.
• W2236157085 hasAuthorship W2236157085A5091651650 @default.
• W2236157085 hasBestOaLocation W22361570852 @default.
• W2236157085 hasConcept C104317684 @default.
• W2236157085 hasConcept C118552586 @default.

• next