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- W2236171617 startingPage "100.41" @default.
- W2236171617 abstract "Abstract Intravenous immunoglobulins (IVIg) are therapeutic preparations of human IgG used to treat primary and secondary immunodeficiencies. In addition, IVIg exert anti-inflammatory effects in several autoimmune disorders, and the constant increase in their use exposes providers and patients to considerable risks of shortage. Understanding their numerous and complex mechanisms of action is required to develop appropriate substitutes. Our research group recently demonstrated that IVIg inhibited the in vitro and in vivo activation of CD4 T cells following interaction with dendritic cells (DC) (Aubin et al, Blood 2010). In the present work, we investigated whether IVIg could also interfere with the activation of CD8 T cells, which contribute to the persistence and severity of certain autoimmune conditions. C57BL/6 bone marrow-derived DC were treated with IVIg and used to cross-present ovalbumin to fluorescently labelled ova-specific OT-I CD8 T cells. Cell activation was assessed by measuring T cell fluorescence distribution by flow cytometry. Results showed that IVIg-treated DC were significantly less efficient in activating CD8 T cells. The inhibition correlated with a decrease in IL-2 and IFN-y pro-inflammatory cytokine secretion. These results support a novel immunomodulatory mechanism by which IVIg decrease DC capacity to cross-present antigens to CD8 T cells. The molecular mechanisms of this inhibition and its importance in vivo are currently being investigated." @default.
- W2236171617 created "2016-06-24" @default.
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- W2236171617 date "2011-04-01" @default.
- W2236171617 modified "2023-09-23" @default.
- W2236171617 title "Inhibition of antigen cross-presentation by intravenous immunoglobulins (100.41)" @default.
- W2236171617 doi "https://doi.org/10.4049/jimmunol.186.supp.100.41" @default.
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