Matches in SemOpenAlex for { <https://semopenalex.org/work/W2236277727> ?p ?o ?g. }
- W2236277727 endingPage "2463" @default.
- W2236277727 startingPage "2455" @default.
- W2236277727 abstract "Myasthenia gravis (MG) is a neuromuscular disease that is conventionally treated with acetylcholinesterase (AChE) inhibitors, which may not fully remove the symptom for many reasons. When AChE inhibitors do not work, Chinese patients turn to Chinese medicine, such as the Buzhongyiqi decoction (BD), to treat MG. By elucidating the relations between the herbs of the Buzhongyiqi decoction recipe and AChE inhibitors with structure-based and ligand-based drug design methods and chemoinformatics approaches, we have found the key active components of BD. Using these key active components as templates, we have discovered five new AChE inhibitors through virtual screening of a commercial compound library. The new AChE inhibitors have been confirmed with Ellman assays. This study demonstrates that lead identification can be inspired by elucidating Chinese medicine. Since BD is a mixture, further studies against other drug targets are needed." @default.
- W2236277727 created "2016-06-24" @default.
- W2236277727 creator A5000545770 @default.
- W2236277727 creator A5002855077 @default.
- W2236277727 creator A5029816792 @default.
- W2236277727 creator A5038906848 @default.
- W2236277727 creator A5071233290 @default.
- W2236277727 creator A5079594267 @default.
- W2236277727 creator A5087729511 @default.
- W2236277727 date "2015-11-11" @default.
- W2236277727 modified "2023-10-18" @default.
- W2236277727 title "Discovering New Acetylcholinesterase Inhibitors by Mining the <i>Buzhongyiqi</i> Decoction Recipe Data" @default.
- W2236277727 cites W13404767 @default.
- W2236277727 cites W1645427546 @default.
- W2236277727 cites W1895993106 @default.
- W2236277727 cites W1968984443 @default.
- W2236277727 cites W1969053334 @default.
- W2236277727 cites W1969340429 @default.
- W2236277727 cites W1971048984 @default.
- W2236277727 cites W1973872488 @default.
- W2236277727 cites W1983404333 @default.
- W2236277727 cites W1986044514 @default.
- W2236277727 cites W1987170637 @default.
- W2236277727 cites W2015461838 @default.
- W2236277727 cites W2015688756 @default.
- W2236277727 cites W2023275299 @default.
- W2236277727 cites W2038258350 @default.
- W2236277727 cites W2041065654 @default.
- W2236277727 cites W2042968563 @default.
- W2236277727 cites W2049988693 @default.
- W2236277727 cites W2056272907 @default.
- W2236277727 cites W2064822275 @default.
- W2236277727 cites W2066051584 @default.
- W2236277727 cites W2069952320 @default.
- W2236277727 cites W2070847106 @default.
- W2236277727 cites W2085138189 @default.
- W2236277727 cites W2087407666 @default.
- W2236277727 cites W2097765803 @default.
- W2236277727 cites W2102399993 @default.
- W2236277727 cites W2102726567 @default.
- W2236277727 cites W2106140689 @default.
- W2236277727 cites W2112006614 @default.
- W2236277727 cites W2118233996 @default.
- W2236277727 cites W2120396743 @default.
- W2236277727 cites W2124679671 @default.
- W2236277727 cites W2135732933 @default.
- W2236277727 cites W2144288821 @default.
- W2236277727 cites W2147993766 @default.
- W2236277727 cites W2157461655 @default.
- W2236277727 cites W2157756755 @default.
- W2236277727 cites W2314966830 @default.
- W2236277727 cites W2381099688 @default.
- W2236277727 cites W3151910712 @default.
- W2236277727 doi "https://doi.org/10.1021/acs.jcim.5b00449" @default.
- W2236277727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26509353" @default.
- W2236277727 hasPublicationYear "2015" @default.
- W2236277727 type Work @default.
- W2236277727 sameAs 2236277727 @default.
- W2236277727 citedByCount "21" @default.
- W2236277727 countsByYear W22362777272016 @default.
- W2236277727 countsByYear W22362777272017 @default.
- W2236277727 countsByYear W22362777272018 @default.
- W2236277727 countsByYear W22362777272019 @default.
- W2236277727 countsByYear W22362777272020 @default.
- W2236277727 countsByYear W22362777272021 @default.
- W2236277727 countsByYear W22362777272022 @default.
- W2236277727 countsByYear W22362777272023 @default.
- W2236277727 crossrefType "journal-article" @default.
- W2236277727 hasAuthorship W2236277727A5000545770 @default.
- W2236277727 hasAuthorship W2236277727A5002855077 @default.
- W2236277727 hasAuthorship W2236277727A5029816792 @default.
- W2236277727 hasAuthorship W2236277727A5038906848 @default.
- W2236277727 hasAuthorship W2236277727A5071233290 @default.
- W2236277727 hasAuthorship W2236277727A5079594267 @default.
- W2236277727 hasAuthorship W2236277727A5087729511 @default.
- W2236277727 hasConcept C103697762 @default.
- W2236277727 hasConcept C126322002 @default.
- W2236277727 hasConcept C142724271 @default.
- W2236277727 hasConcept C147597530 @default.
- W2236277727 hasConcept C181199279 @default.
- W2236277727 hasConcept C185592680 @default.
- W2236277727 hasConcept C188947578 @default.
- W2236277727 hasConcept C190409667 @default.
- W2236277727 hasConcept C204787440 @default.
- W2236277727 hasConcept C2778105408 @default.
- W2236277727 hasConcept C2778816929 @default.
- W2236277727 hasConcept C2779059548 @default.
- W2236277727 hasConcept C2779101902 @default.
- W2236277727 hasConcept C2780035454 @default.
- W2236277727 hasConcept C55493867 @default.
- W2236277727 hasConcept C556039675 @default.
- W2236277727 hasConcept C68762167 @default.
- W2236277727 hasConcept C71924100 @default.
- W2236277727 hasConcept C74187038 @default.
- W2236277727 hasConcept C98274493 @default.
- W2236277727 hasConceptScore W2236277727C103697762 @default.
- W2236277727 hasConceptScore W2236277727C126322002 @default.
- W2236277727 hasConceptScore W2236277727C142724271 @default.