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• W2236352122 abstract "Monoamine oxidase (MAO) catalyzes the oxidative deamination of monoamines including dopamine (DA). MAO expression is elevated in Parkinson’s disease (PD). An increase in MAO activity is closely related to age, and this may induce neuronal degeneration in the brain due to oxidative stress. MAO (and particularly monoamine oxidase B (MAO-B)) participates in the generation of reactive oxygen species (ROS), such as hydrogen peroxide that are toxic to dopaminergic cells and their surroundings. Although the polyphenol-rich aqueous walnut extract (JSE; an extract of Juglandis Semen) has been shown to have various beneficial bioactivities, no study has been dedicated to see if JSE is capable to protect dopaminergic neurons against neurotoxic insults in models of PD. In the present study we investigated the neuroprotective potential of JSE against 1-methyl-4-phenylpyridinium (MPP+)- or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicities in primary mesencephalic cells and in a mouse model of PD. Here we show that JSE treatment suppressed ROS and nitric oxide productions triggered by MPP+ in primary mesencephalic cells. JSE also inhibited depletion of striatal DA and its metabolites in vivo that resulted in significant improvement in PD-like movement impairment. Altogether our results indicate that JSE has neuroprotective effects in PD models and may have potential for the prevention or treatment of PD." @default.
• W2236352122 created "2016-06-24" @default.
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• W2236352122 creator A5085462551 @default.
• W2236352122 date "2016-01-15" @default.
• W2236352122 modified "2023-09-24" @default.
• W2236352122 title "In Vitro and in Vivo Neuroprotective Effects of Walnut (Juglandis Semen) in Models of Parkinson’s Disease" @default.
• W2236352122 cites W1506563231 @default.
• W2236352122 cites W1969480665 @default.
• W2236352122 cites W1969772140 @default.
• W2236352122 cites W1970447912 @default.
• W2236352122 cites W1971389338 @default.
• W2236352122 cites W1979435015 @default.
• W2236352122 cites W1979786583 @default.
• W2236352122 cites W1979859269 @default.
• W2236352122 cites W1984285213 @default.
• W2236352122 cites W1987700370 @default.
• W2236352122 cites W1988560967 @default.
• W2236352122 cites W1991128766 @default.
• W2236352122 cites W1994676012 @default.
• W2236352122 cites W1999633128 @default.
• W2236352122 cites W1999713485 @default.
• W2236352122 cites W2003341268 @default.
• W2236352122 cites W2005698271 @default.
• W2236352122 cites W2011341174 @default.
• W2236352122 cites W2013914182 @default.
• W2236352122 cites W2014168928 @default.
• W2236352122 cites W2016679663 @default.
• W2236352122 cites W2019211900 @default.
• W2236352122 cites W2021935429 @default.
• W2236352122 cites W2023224520 @default.
• W2236352122 cites W2024146316 @default.
• W2236352122 cites W2027432236 @default.
• W2236352122 cites W2031726810 @default.
• W2236352122 cites W2033187357 @default.
• W2236352122 cites W2036153851 @default.
• W2236352122 cites W2039437431 @default.
• W2236352122 cites W2041437265 @default.
• W2236352122 cites W2049588777 @default.
• W2236352122 cites W2049805159 @default.
• W2236352122 cites W2052384228 @default.
• W2236352122 cites W2055359939 @default.
• W2236352122 cites W2056837063 @default.
• W2236352122 cites W2058688226 @default.
• W2236352122 cites W2059127513 @default.
• W2236352122 cites W2062993762 @default.
• W2236352122 cites W2069356567 @default.
• W2236352122 cites W2073632963 @default.
• W2236352122 cites W2076576091 @default.
• W2236352122 cites W2077260129 @default.
• W2236352122 cites W2082240838 @default.
• W2236352122 cites W2086887101 @default.
• W2236352122 cites W2087645296 @default.
• W2236352122 cites W2088620464 @default.
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• W2236352122 cites W2095374280 @default.
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• W2236352122 cites W2111646903 @default.
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• W2236352122 cites W2120496925 @default.
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• W2236352122 cites W2140294024 @default.
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• W2236352122 cites W2148574282 @default.
• W2236352122 cites W2148954621 @default.
• W2236352122 cites W2151740819 @default.
• W2236352122 cites W2153122362 @default.
• W2236352122 cites W2157257950 @default.
• W2236352122 cites W2158030535 @default.
• W2236352122 cites W2169890833 @default.
• W2236352122 cites W2189551121 @default.
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• W2236352122 doi "https://doi.org/10.3390/ijms17010108" @default.
• W2236352122 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4730349" @default.
• W2236352122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26784178" @default.
• W2236352122 hasPublicationYear "2016" @default.
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