Matches in SemOpenAlex for { <https://semopenalex.org/work/W2236452202> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2236452202 endingPage "7" @default.
- W2236452202 startingPage "2543" @default.
- W2236452202 abstract "While intra-articular injection of sinomenine hydrochloride has a therapeutic effect on osteoarthritis, it has a short half-life, and is thermolabile and photolabile. The aim of this research was to evaluate the sustained-release of sinomenine hydrochloride from an injectable sinomenine hydrochloride and sodium hyaluronate compound (CSSSI) and its therapeutic effect in a rabbit model of osteoarthritis following intra-articular injection.An injectable compound consisting of 1% sodium hyaluronate and 2.5% sinomenine hydrochloride was prepared and kept as the experiment group, and 2.5% sinomenine hydrochloride was prepared and kept as the control group. The cumulative mass release was measured at different time points in each group in vitro. Sixty-five male Zelanian rabbits were randomly divided into five groups: 15 (30 knees) each for the control, sodium hyaluronate, sinomenine hydrochloride, and CSSSI groups respectively, and five (10 knees) for the modeling group. Papain was injected into both knees of each rabbit for model establishment. Subsequently, 0.2 ml of the corresponding drugs was injected into the articular cavities of the remaining experiment groups, while the control group was treated with 0.2 ml normal saline. All groups were treated once a week for 4 weeks. Seven days after the last treatment, knees were anatomized to perform pathological observations and Mankin's evaluation of the synovium. Four groups were compared using the SPSS 13.0 software package.In the in vitro sustained-release experiments, 90% of the drug was released in the experiment group 360 minutes following the injection. Comparison of the Mankin's evaluations of the four groups illustrated statistical discrepancies (P < 0.05). In further paired comparisons of the CSSSI group vs. modeling control/sodium hyaluronate/sinomenine hydrochloride groups, statistical significance was uniformly obtained. Moreover, sodium hyaluronate and sinomenine hydrochloride treatments showed significant improvement over the modeling control (P < 0.05), whereas sodium hyaluronate vs. sinomenine hydrochloride comparison failed to reach significance (P > 0.05).CSSSI has a sustained-release effect on sinomenine hydrochloride. Intra-articular injection of CSSSI was significantly better than the sole sodium hyaluronate or sinomenine hydrochloride for the treatment of osteoarthritis in a rabbit model." @default.
- W2236452202 created "2016-06-24" @default.
- W2236452202 creator A5008361487 @default.
- W2236452202 creator A5011960711 @default.
- W2236452202 creator A5018353132 @default.
- W2236452202 creator A5032620251 @default.
- W2236452202 creator A5039716603 @default.
- W2236452202 creator A5055497207 @default.
- W2236452202 creator A5070700368 @default.
- W2236452202 creator A5073397955 @default.
- W2236452202 creator A5077781605 @default.
- W2236452202 creator A5083726106 @default.
- W2236452202 date "2012-07-01" @default.
- W2236452202 modified "2023-10-18" @default.
- W2236452202 title "Therapeutic effect of an injectable sustained-release sinomenine hydrochloride and sodium hyaluronate compound in a rabbit model of osteoarthritis." @default.
- W2236452202 cites W133193440 @default.
- W2236452202 cites W1990447841 @default.
- W2236452202 cites W1991507289 @default.
- W2236452202 cites W2001128404 @default.
- W2236452202 cites W2038874473 @default.
- W2236452202 cites W2061550234 @default.
- W2236452202 cites W2123561576 @default.
- W2236452202 cites W2157236187 @default.
- W2236452202 cites W2316072377 @default.
- W2236452202 cites W2417480659 @default.
- W2236452202 cites W342856410 @default.
- W2236452202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22931995" @default.
- W2236452202 hasPublicationYear "2012" @default.
- W2236452202 type Work @default.
- W2236452202 sameAs 2236452202 @default.
- W2236452202 citedByCount "4" @default.
- W2236452202 countsByYear W22364522022016 @default.
- W2236452202 countsByYear W22364522022020 @default.
- W2236452202 countsByYear W22364522022022 @default.
- W2236452202 crossrefType "journal-article" @default.
- W2236452202 hasAuthorship W2236452202A5008361487 @default.
- W2236452202 hasAuthorship W2236452202A5011960711 @default.
- W2236452202 hasAuthorship W2236452202A5018353132 @default.
- W2236452202 hasAuthorship W2236452202A5032620251 @default.
- W2236452202 hasAuthorship W2236452202A5039716603 @default.
- W2236452202 hasAuthorship W2236452202A5055497207 @default.
- W2236452202 hasAuthorship W2236452202A5070700368 @default.
- W2236452202 hasAuthorship W2236452202A5073397955 @default.
- W2236452202 hasAuthorship W2236452202A5077781605 @default.
- W2236452202 hasAuthorship W2236452202A5083726106 @default.
- W2236452202 hasConcept C105702510 @default.
- W2236452202 hasConcept C142724271 @default.
- W2236452202 hasConcept C185592680 @default.
- W2236452202 hasConcept C204787440 @default.
- W2236452202 hasConcept C2776164576 @default.
- W2236452202 hasConcept C2776460385 @default.
- W2236452202 hasConcept C2777397205 @default.
- W2236452202 hasConcept C2777529286 @default.
- W2236452202 hasConcept C2777662524 @default.
- W2236452202 hasConcept C2777917749 @default.
- W2236452202 hasConcept C42219234 @default.
- W2236452202 hasConcept C43617362 @default.
- W2236452202 hasConcept C55493867 @default.
- W2236452202 hasConcept C71924100 @default.
- W2236452202 hasConcept C98274493 @default.
- W2236452202 hasConceptScore W2236452202C105702510 @default.
- W2236452202 hasConceptScore W2236452202C142724271 @default.
- W2236452202 hasConceptScore W2236452202C185592680 @default.
- W2236452202 hasConceptScore W2236452202C204787440 @default.
- W2236452202 hasConceptScore W2236452202C2776164576 @default.
- W2236452202 hasConceptScore W2236452202C2776460385 @default.
- W2236452202 hasConceptScore W2236452202C2777397205 @default.
- W2236452202 hasConceptScore W2236452202C2777529286 @default.
- W2236452202 hasConceptScore W2236452202C2777662524 @default.
- W2236452202 hasConceptScore W2236452202C2777917749 @default.
- W2236452202 hasConceptScore W2236452202C42219234 @default.
- W2236452202 hasConceptScore W2236452202C43617362 @default.
- W2236452202 hasConceptScore W2236452202C55493867 @default.
- W2236452202 hasConceptScore W2236452202C71924100 @default.
- W2236452202 hasConceptScore W2236452202C98274493 @default.
- W2236452202 hasIssue "14" @default.
- W2236452202 hasLocation W22364522021 @default.
- W2236452202 hasOpenAccess W2236452202 @default.
- W2236452202 hasPrimaryLocation W22364522021 @default.
- W2236452202 hasRelatedWork W1985915038 @default.
- W2236452202 hasRelatedWork W2002580821 @default.
- W2236452202 hasRelatedWork W2055973157 @default.
- W2236452202 hasRelatedWork W2097619910 @default.
- W2236452202 hasRelatedWork W2352377154 @default.
- W2236452202 hasRelatedWork W2357671566 @default.
- W2236452202 hasRelatedWork W2359726149 @default.
- W2236452202 hasRelatedWork W2617599704 @default.
- W2236452202 hasRelatedWork W2899084033 @default.
- W2236452202 hasRelatedWork W3032423656 @default.
- W2236452202 hasVolume "125" @default.
- W2236452202 isParatext "false" @default.
- W2236452202 isRetracted "false" @default.
- W2236452202 magId "2236452202" @default.
- W2236452202 workType "article" @default.