Matches in SemOpenAlex for { <https://semopenalex.org/work/W2236570129> ?p ?o ?g. }
- W2236570129 endingPage "174" @default.
- W2236570129 startingPage "149" @default.
- W2236570129 abstract "Curcumin (diferuloylmethane) is the biphenolic active compound of turmeric. Curcumin has been used for hundreds of years to treat various ailments. Curcumin has been reported to exert numerous pharmacological effects by modulating multiple molecular targets including those involved in the pathogenesis of cancer. Cancer has been characterized as the dysregulation of cell signaling pathways through gradual alteration of regulatory proteins and through gene mutation. Curcumin is a highly pleiotropic molecule that modulates several intracellular signaling pathways in cancer. The pleiotropic activities of curcumin have been attributed to its novel molecular structure. Based on its β-diketone moiety, curcumin exists in keto-enol tautomers, and this tautomerism favors interaction and binding with a wide range of enzymes. Several studies have shown modulation of numerous signaling enzymes by curcumin including, LOX, COX-2, XO, proteasomes, Ca(2+)-ATPase of sarcoplasmic reticulum, MMPs, HAT, HDAC, DNMT1, DNA polymerase λ, ribonucleases, GloI, protein kinases (PKA, PKB, PKC, v-Src, GSK-3β, ErbB2), protein reductases (TrxR1, AR), GSH, ICDHs, peroxidases (Prx1, Prx2, Prx6) by treatment with curcumin. Various biophysical analyses have been reported, which shows the underlying molecular interaction of curcumin with multiple targets in terms of binding affinities. The current chapter describes how curcumin binds and modulates multiple enzymes involved cancer. Published clinical trial studies with curcumin in cancer management will also be discussed." @default.
- W2236570129 created "2016-06-24" @default.
- W2236570129 creator A5021258379 @default.
- W2236570129 creator A5045591060 @default.
- W2236570129 creator A5086170220 @default.
- W2236570129 date "2014-01-01" @default.
- W2236570129 modified "2023-10-18" @default.
- W2236570129 title "Curcumin" @default.
- W2236570129 cites W113066918 @default.
- W2236570129 cites W1588188747 @default.
- W2236570129 cites W1602112773 @default.
- W2236570129 cites W1604068141 @default.
- W2236570129 cites W1964757070 @default.
- W2236570129 cites W1965144265 @default.
- W2236570129 cites W1967064679 @default.
- W2236570129 cites W1972519024 @default.
- W2236570129 cites W1974589206 @default.
- W2236570129 cites W1974722562 @default.
- W2236570129 cites W1986581020 @default.
- W2236570129 cites W1986618479 @default.
- W2236570129 cites W1987496015 @default.
- W2236570129 cites W1987736530 @default.
- W2236570129 cites W1987825791 @default.
- W2236570129 cites W1988492454 @default.
- W2236570129 cites W1988710285 @default.
- W2236570129 cites W1994193544 @default.
- W2236570129 cites W2003500892 @default.
- W2236570129 cites W2005839352 @default.
- W2236570129 cites W2007639487 @default.
- W2236570129 cites W2008107953 @default.
- W2236570129 cites W2008353852 @default.
- W2236570129 cites W2008665179 @default.
- W2236570129 cites W2008745096 @default.
- W2236570129 cites W2009897558 @default.
- W2236570129 cites W2010556228 @default.
- W2236570129 cites W2014203415 @default.
- W2236570129 cites W2017764127 @default.
- W2236570129 cites W2018438378 @default.
- W2236570129 cites W2024726092 @default.
- W2236570129 cites W2024984581 @default.
- W2236570129 cites W2026145579 @default.
- W2236570129 cites W2028556682 @default.
- W2236570129 cites W2031673279 @default.
- W2236570129 cites W2032169268 @default.
- W2236570129 cites W2035881613 @default.
- W2236570129 cites W2036330645 @default.
- W2236570129 cites W2036813543 @default.
- W2236570129 cites W2037175822 @default.
- W2236570129 cites W2038458062 @default.
- W2236570129 cites W2039562363 @default.
- W2236570129 cites W2040257851 @default.
- W2236570129 cites W2040942754 @default.
- W2236570129 cites W2041246372 @default.
- W2236570129 cites W2041544048 @default.
- W2236570129 cites W2048458354 @default.
- W2236570129 cites W2051380662 @default.
- W2236570129 cites W2056195849 @default.
- W2236570129 cites W2056996437 @default.
- W2236570129 cites W2057903885 @default.
- W2236570129 cites W2058046287 @default.
- W2236570129 cites W2059176821 @default.
- W2236570129 cites W2059218794 @default.
- W2236570129 cites W2060857477 @default.
- W2236570129 cites W2065993983 @default.
- W2236570129 cites W2067330776 @default.
- W2236570129 cites W2068004114 @default.
- W2236570129 cites W2070889802 @default.
- W2236570129 cites W2073699206 @default.
- W2236570129 cites W2073825819 @default.
- W2236570129 cites W2079178816 @default.
- W2236570129 cites W2079479745 @default.
- W2236570129 cites W2080724286 @default.
- W2236570129 cites W2080964680 @default.
- W2236570129 cites W2080992186 @default.
- W2236570129 cites W2082849973 @default.
- W2236570129 cites W2083834906 @default.
- W2236570129 cites W2084583180 @default.
- W2236570129 cites W2084585471 @default.
- W2236570129 cites W2086046451 @default.
- W2236570129 cites W2090703365 @default.
- W2236570129 cites W2094678858 @default.
- W2236570129 cites W2095054695 @default.
- W2236570129 cites W2096076362 @default.
- W2236570129 cites W2096098783 @default.
- W2236570129 cites W2096743657 @default.
- W2236570129 cites W2103146402 @default.
- W2236570129 cites W2108706315 @default.
- W2236570129 cites W2109126671 @default.
- W2236570129 cites W2113956002 @default.
- W2236570129 cites W2114594254 @default.
- W2236570129 cites W2115097854 @default.
- W2236570129 cites W2115400066 @default.
- W2236570129 cites W2122480988 @default.
- W2236570129 cites W2123375980 @default.
- W2236570129 cites W2127191722 @default.
- W2236570129 cites W2127621044 @default.
- W2236570129 cites W2128399547 @default.
- W2236570129 cites W2129397604 @default.