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- W2236623169 abstract "SummaryThe effect of the 5-HT1A agonist ipsapirone on behaviour and plasma corticosterone levels was studied in the same male Wistar rats before and after psychosocial stress of defeat. Ipsapirone in a dose of 5 mg/kg i.p. failed to affect corticosterone levels before social stress whereas after defeat the hormone response was much higher than in drug-free controls. The exaggerated stress response and particularly the presence of high post-defeat corticosterone levels in ipsapirone treated rats already before the exposure to the dominant rat lead to the hypothesis that postsynaptic 5-HT1A receptor hypersensitivity develops after stress of defeat." @default.
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- W2236623169 date "1991-01-01" @default.
- W2236623169 modified "2023-09-26" @default.
- W2236623169 title "Neuroendocrine Evidence for Hypersensitivity in Serotonergic Neuronal System after Psychosocial Stress of Defeat" @default.
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- W2236623169 doi "https://doi.org/10.1007/978-3-0348-6419-0_17" @default.
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