Matches in SemOpenAlex for { <https://semopenalex.org/work/W2236636770> ?p ?o ?g. }
- W2236636770 endingPage "178" @default.
- W2236636770 startingPage "166" @default.
- W2236636770 abstract "MHC class I-related chain A (MICA) is a principal immunoligand of the natural killer (NK) cell receptor NK group 2, member D (NKG2D) and plays a key role in NK cell-mediated immune recognition. Shedding of MICA from tumor cells leads to immunosuppression. To reconstitute the immunosurveilance function of NK cells, we constructed a fusion protein rG7S-MICA and explored its potential anti-tumor activity against hepatocellular carcinoma (HCC). rG7S-MICA consists of human MICA and a single-chain antibody fragment (scFv) targeting the tumor-associated antigen cluster of differentiation 24 (CD24). In vitro, rG7S-MICA engaged both NK cells and CD24+ human HCC cells, and triggered NK cell-mediated cytolysis. Furthermore, in CD24+ HCC-bearing nude mice, rG7S-MICA specifically targeted to the tumor tissue, where it effectively recruited NK cells and induced the release of cytokines, and showed superior anti-tumor activity. In conclusion, rG7S-MICA provides a new approach for HCC-targeting immunotherapy and has attracting potentials for clinical applications." @default.
- W2236636770 created "2016-06-24" @default.
- W2236636770 creator A5015102287 @default.
- W2236636770 creator A5042940004 @default.
- W2236636770 creator A5045703368 @default.
- W2236636770 creator A5049074106 @default.
- W2236636770 creator A5069858389 @default.
- W2236636770 creator A5073362919 @default.
- W2236636770 creator A5073630988 @default.
- W2236636770 creator A5083455588 @default.
- W2236636770 creator A5084133517 @default.
- W2236636770 date "2016-03-01" @default.
- W2236636770 modified "2023-10-15" @default.
- W2236636770 title "A bispecific protein rG7S-MICA recruits natural killer cells and enhances NKG2D-mediated immunosurveillance against hepatocellular carcinoma" @default.
- W2236636770 cites W1037888931 @default.
- W2236636770 cites W1539873584 @default.
- W2236636770 cites W1541232837 @default.
- W2236636770 cites W1575629882 @default.
- W2236636770 cites W1867495648 @default.
- W2236636770 cites W1970527277 @default.
- W2236636770 cites W1985576417 @default.
- W2236636770 cites W1989565979 @default.
- W2236636770 cites W1999420561 @default.
- W2236636770 cites W2002155693 @default.
- W2236636770 cites W2014144836 @default.
- W2236636770 cites W2017290057 @default.
- W2236636770 cites W2020509813 @default.
- W2236636770 cites W2021201593 @default.
- W2236636770 cites W2027268124 @default.
- W2236636770 cites W2032341321 @default.
- W2236636770 cites W2033439473 @default.
- W2236636770 cites W2041515126 @default.
- W2236636770 cites W2042108891 @default.
- W2236636770 cites W2043162780 @default.
- W2236636770 cites W2061084780 @default.
- W2236636770 cites W2064920472 @default.
- W2236636770 cites W2065561060 @default.
- W2236636770 cites W2067814594 @default.
- W2236636770 cites W2068424305 @default.
- W2236636770 cites W2078950332 @default.
- W2236636770 cites W2092285890 @default.
- W2236636770 cites W2092759077 @default.
- W2236636770 cites W2100106896 @default.
- W2236636770 cites W2101031676 @default.
- W2236636770 cites W2113811237 @default.
- W2236636770 cites W2126553848 @default.
- W2236636770 cites W2135568473 @default.
- W2236636770 cites W2136977965 @default.
- W2236636770 cites W2138424758 @default.
- W2236636770 cites W2144872368 @default.
- W2236636770 cites W2153355346 @default.
- W2236636770 cites W2169204159 @default.
- W2236636770 cites W2170753831 @default.
- W2236636770 cites W2172020436 @default.
- W2236636770 cites W2240151541 @default.
- W2236636770 cites W2532302040 @default.
- W2236636770 cites W306580226 @default.
- W2236636770 cites W1989868942 @default.
- W2236636770 doi "https://doi.org/10.1016/j.canlet.2016.01.001" @default.
- W2236636770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26791237" @default.
- W2236636770 hasPublicationYear "2016" @default.
- W2236636770 type Work @default.
- W2236636770 sameAs 2236636770 @default.
- W2236636770 citedByCount "39" @default.
- W2236636770 countsByYear W22366367702016 @default.
- W2236636770 countsByYear W22366367702017 @default.
- W2236636770 countsByYear W22366367702018 @default.
- W2236636770 countsByYear W22366367702019 @default.
- W2236636770 countsByYear W22366367702020 @default.
- W2236636770 countsByYear W22366367702021 @default.
- W2236636770 countsByYear W22366367702022 @default.
- W2236636770 countsByYear W22366367702023 @default.
- W2236636770 crossrefType "journal-article" @default.
- W2236636770 hasAuthorship W2236636770A5015102287 @default.
- W2236636770 hasAuthorship W2236636770A5042940004 @default.
- W2236636770 hasAuthorship W2236636770A5045703368 @default.
- W2236636770 hasAuthorship W2236636770A5049074106 @default.
- W2236636770 hasAuthorship W2236636770A5069858389 @default.
- W2236636770 hasAuthorship W2236636770A5073362919 @default.
- W2236636770 hasAuthorship W2236636770A5073630988 @default.
- W2236636770 hasAuthorship W2236636770A5083455588 @default.
- W2236636770 hasAuthorship W2236636770A5084133517 @default.
- W2236636770 hasConcept C109316439 @default.
- W2236636770 hasConcept C129374314 @default.
- W2236636770 hasConcept C170627219 @default.
- W2236636770 hasConcept C202751555 @default.
- W2236636770 hasConcept C203014093 @default.
- W2236636770 hasConcept C207936829 @default.
- W2236636770 hasConcept C2776090121 @default.
- W2236636770 hasConcept C2776885095 @default.
- W2236636770 hasConcept C2777701055 @default.
- W2236636770 hasConcept C2778102761 @default.
- W2236636770 hasConcept C2778867473 @default.
- W2236636770 hasConcept C28651165 @default.
- W2236636770 hasConcept C502942594 @default.
- W2236636770 hasConcept C55493867 @default.
- W2236636770 hasConcept C86803240 @default.
- W2236636770 hasConcept C8891405 @default.