FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2236660254> ?p ?o ?g. }

• W2236660254 abstract "In spite of progress in diagnostics and treatment of Hepatocellular Carcinoma (HCC), its prognosis remains poor, and improved treatment strategies for HCC require detailed understanding of the underlying mechanism. In this investigation we studied the role of Up-frameshift 1 (UPF1) in the tumorigenesis of HCC.We determined the expression level of UPF1 in HCC tissues with quantitative real-time PCR and western blotting and then studied its clinical significance. Sodium bisulfite sequencing was used to investigate the regulation of UPF1. We explored the biological significance of UPF1 with gain-and-loss-of-function analyses both in vitro and in vivo. The relationship between UPF1 and SMAD7 was also investigated by western blotting and immunofluorescence.A great downregulation of UPF1 due to promoter hypermethylation was observed in tumor tissues compared to their adjacent normal tissues. Meanwhile, patients with low UPF1 expression have significantly poorer prognosis than those with high expression. Functionally, UPF1 regulated HCC tumorigenesis both in vitro and in vivo. Moreover, the decreased UPF1 level in HCC reduces NMD efficiency and leads to up-regulation of Smad7, then affects the TGF-β pathway.Our findings revealed that UPF1 is a potential tumor suppressive gene and may be a potential therapeutic target for HCC." @default.
• W2236660254 created "2016-06-24" @default.
• W2236660254 creator A5014384556 @default.
• W2236660254 creator A5028828133 @default.
• W2236660254 creator A5040280498 @default.
• W2236660254 creator A5040796539 @default.
• W2236660254 creator A5045384691 @default.
• W2236660254 creator A5053817652 @default.
• W2236660254 creator A5069088751 @default.
• W2236660254 creator A5075781632 @default.
• W2236660254 creator A5083374325 @default.
• W2236660254 date "2016-01-13" @default.
• W2236660254 modified "2023-10-14" @default.
• W2236660254 title "The human RNA surveillance factor UPF1 regulates tumorigenesis by targeting Smad7 in hepatocellular carcinoma" @default.
• W2236660254 cites W1975117841 @default.
• W2236660254 cites W1976407358 @default.
• W2236660254 cites W1985645826 @default.
• W2236660254 cites W1997980793 @default.
• W2236660254 cites W1999937586 @default.
• W2236660254 cites W2003419284 @default.
• W2236660254 cites W2005716799 @default.
• W2236660254 cites W2009757848 @default.
• W2236660254 cites W2010798304 @default.
• W2236660254 cites W2011452661 @default.
• W2236660254 cites W2013770032 @default.
• W2236660254 cites W2021518210 @default.
• W2236660254 cites W2024039709 @default.
• W2236660254 cites W2044987787 @default.
• W2236660254 cites W2060893815 @default.
• W2236660254 cites W2065194008 @default.
• W2236660254 cites W2084212780 @default.
• W2236660254 cites W2133902192 @default.
• W2236660254 cites W2135948917 @default.
• W2236660254 cites W2137052325 @default.
• W2236660254 cites W2145595073 @default.
• W2236660254 cites W2147518722 @default.
• W2236660254 cites W2151627051 @default.
• W2236660254 cites W2156086097 @default.
• W2236660254 cites W2167527034 @default.
• W2236660254 cites W2178988142 @default.
• W2236660254 cites W2396482369 @default.
• W2236660254 cites W2409204846 @default.
• W2236660254 doi "https://doi.org/10.1186/s13046-016-0286-2" @default.
• W2236660254 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4711019" @default.
• W2236660254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26759305" @default.
• W2236660254 hasPublicationYear "2016" @default.
• W2236660254 type Work @default.
• W2236660254 sameAs 2236660254 @default.
• W2236660254 citedByCount "53" @default.
• W2236660254 countsByYear W22366602542016 @default.
• W2236660254 countsByYear W22366602542017 @default.
• W2236660254 countsByYear W22366602542018 @default.
• W2236660254 countsByYear W22366602542019 @default.
• W2236660254 countsByYear W22366602542020 @default.
• W2236660254 countsByYear W22366602542021 @default.
• W2236660254 countsByYear W22366602542022 @default.
• W2236660254 countsByYear W22366602542023 @default.
• W2236660254 crossrefType "journal-article" @default.
• W2236660254 hasAuthorship W2236660254A5014384556 @default.
• W2236660254 hasAuthorship W2236660254A5028828133 @default.
• W2236660254 hasAuthorship W2236660254A5040280498 @default.
• W2236660254 hasAuthorship W2236660254A5040796539 @default.
• W2236660254 hasAuthorship W2236660254A5045384691 @default.
• W2236660254 hasAuthorship W2236660254A5053817652 @default.
• W2236660254 hasAuthorship W2236660254A5069088751 @default.
• W2236660254 hasAuthorship W2236660254A5075781632 @default.
• W2236660254 hasAuthorship W2236660254A5083374325 @default.
• W2236660254 hasBestOaLocation W22366602541 @default.
• W2236660254 hasConcept C104317684 @default.
• W2236660254 hasConcept C121608353 @default.
• W2236660254 hasConcept C127561419 @default.
• W2236660254 hasConcept C153911025 @default.
• W2236660254 hasConcept C173396325 @default.
• W2236660254 hasConcept C185592680 @default.
• W2236660254 hasConcept C190283241 @default.
• W2236660254 hasConcept C207001950 @default.
• W2236660254 hasConcept C2778019345 @default.
• W2236660254 hasConcept C502942594 @default.
• W2236660254 hasConcept C54355233 @default.
• W2236660254 hasConcept C555283112 @default.
• W2236660254 hasConcept C85265743 @default.
• W2236660254 hasConcept C86803240 @default.
• W2236660254 hasConceptScore W2236660254C104317684 @default.
• W2236660254 hasConceptScore W2236660254C121608353 @default.
• W2236660254 hasConceptScore W2236660254C127561419 @default.
• W2236660254 hasConceptScore W2236660254C153911025 @default.
• W2236660254 hasConceptScore W2236660254C173396325 @default.
• W2236660254 hasConceptScore W2236660254C185592680 @default.
• W2236660254 hasConceptScore W2236660254C190283241 @default.
• W2236660254 hasConceptScore W2236660254C207001950 @default.
• W2236660254 hasConceptScore W2236660254C2778019345 @default.
• W2236660254 hasConceptScore W2236660254C502942594 @default.
• W2236660254 hasConceptScore W2236660254C54355233 @default.
• W2236660254 hasConceptScore W2236660254C555283112 @default.
• W2236660254 hasConceptScore W2236660254C85265743 @default.
• W2236660254 hasConceptScore W2236660254C86803240 @default.
• W2236660254 hasFunder F4320321001 @default.
• W2236660254 hasIssue "1" @default.
• W2236660254 hasLocation W22366602541 @default.
• W2236660254 hasLocation W22366602542 @default.

• next