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- W2236670836 endingPage "e0146585" @default.
- W2236670836 startingPage "e0146585" @default.
- W2236670836 abstract "Tuberculosis and nontuberculous mycobacterial infections constitute a high burden of pulmonary disease in humans, resulting in over 1.5 million deaths per year. Building on the premise that genetic factors influence the instance, progression, and defense of infectious disease, we undertook a systems biology approach to investigate relationships among genetic factors that may play a role in increased susceptibility or control of mycobacterial infections. We combined literature and database mining with network analysis and pathway enrichment analysis to examine genes, pathways, and networks, involved in the human response to Mycobacterium tuberculosis and nontuberculous mycobacterial infections. This approach allowed us to examine functional relationships among reported genes, and to identify novel genes and enriched pathways that may play a role in mycobacterial susceptibility or control. Our findings suggest that the primary pathways and genes influencing mycobacterial infection control involve an interplay between innate and adaptive immune proteins and pathways. Signaling pathways involved in autoimmune disease were significantly enriched as revealed in our networks. Mycobacterial disease susceptibility networks were also examined within the context of gene-chemical relationships, in order to identify putative drugs and nutrients with potential beneficial immunomodulatory or anti-mycobacterial effects." @default.
- W2236670836 created "2016-06-24" @default.
- W2236670836 creator A5003748507 @default.
- W2236670836 creator A5012758032 @default.
- W2236670836 creator A5079774065 @default.
- W2236670836 date "2016-01-11" @default.
- W2236670836 modified "2023-09-25" @default.
- W2236670836 title "Network Analysis of Human Genes Influencing Susceptibility to Mycobacterial Infections" @default.
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