Matches in SemOpenAlex for { <https://semopenalex.org/work/W2236679049> ?p ?o ?g. }
- W2236679049 abstract "Abstract Total knee replacement (TKR) is a common therapeutic option to restore joint functionality in chronic inflammatory joint diseases. Subsequent arthrofibrotic remodeling occurs in 10%, but the underlying pathomechanisms remain unclear. We evaluated the association of xylosyltransferases (XT), fibrotic mediators catalyzing glycosaminoglycan biosynthesis, leading to arthrofibrosis as well as the feasibility of using serum XT activity as a diagnostic marker. For this purpose, synovial fibroblasts (SF) were isolated from arthrofibrotic and control synovial biopsies. Basal α-smooth muscle actin expression revealed a high fibroblast-myofibroblast transition rate in arthrofibrotic fibroblasts. Fibrotic remodeling marked by enhanced XT activity, α-SMA protein expression as well as xylosyltransferase-I, collagen type III-alpha-1 and ACTA2 mRNA expression was stronger in arthrofibrotic than in control fibroblasts treated with transforming growth factor-β1 (TGF-β1). Otherwise, no differences between serum levels of XT-I activity or common fibrosis markers (galectin-3 and growth differentiation factor-15 levels (GDF-15)) were found between 95 patients with arthrofibrosis and 132 controls after TKR. In summary, XT-I was initially investigated as a key cellular mediator of arthrofibrosis and a target for therapeutic intervention. However, the blood-synovial-barrier makes arthrofibrotic molecular changes undetectable in serum. Future studies on monitoring or preventing arthrofibrotic remodeling should therefore rely on local instead of systemic parameters." @default.
- W2236679049 created "2016-06-24" @default.
- W2236679049 creator A5031087323 @default.
- W2236679049 creator A5037149734 @default.
- W2236679049 creator A5040796037 @default.
- W2236679049 creator A5056182768 @default.
- W2236679049 creator A5062578726 @default.
- W2236679049 creator A5065791157 @default.
- W2236679049 creator A5076820743 @default.
- W2236679049 creator A5086960835 @default.
- W2236679049 creator A5090963306 @default.
- W2236679049 date "2015-07-28" @default.
- W2236679049 modified "2023-09-27" @default.
- W2236679049 title "Human xylosyltransferases – mediators of arthrofibrosis? New pathomechanistic insights into arthrofibrotic remodeling after knee replacement therapy" @default.
- W2236679049 cites W100674810 @default.
- W2236679049 cites W12055603 @default.
- W2236679049 cites W1566633452 @default.
- W2236679049 cites W1577577364 @default.
- W2236679049 cites W1604036230 @default.
- W2236679049 cites W1959272718 @default.
- W2236679049 cites W1972233590 @default.
- W2236679049 cites W1980763629 @default.
- W2236679049 cites W1981269419 @default.
- W2236679049 cites W1981406615 @default.
- W2236679049 cites W1983337952 @default.
- W2236679049 cites W1995528629 @default.
- W2236679049 cites W2005161538 @default.
- W2236679049 cites W2013283042 @default.
- W2236679049 cites W2015787457 @default.
- W2236679049 cites W2021539651 @default.
- W2236679049 cites W2022631529 @default.
- W2236679049 cites W2023815961 @default.
- W2236679049 cites W2025287936 @default.
- W2236679049 cites W2027759051 @default.
- W2236679049 cites W2030959531 @default.
- W2236679049 cites W2034426198 @default.
- W2236679049 cites W2035268991 @default.
- W2236679049 cites W2036304113 @default.
- W2236679049 cites W2046820460 @default.
- W2236679049 cites W2053675513 @default.
- W2236679049 cites W2054500578 @default.
- W2236679049 cites W2058396418 @default.
- W2236679049 cites W2067277410 @default.
- W2236679049 cites W2068452558 @default.
- W2236679049 cites W2074347694 @default.
- W2236679049 cites W2082317371 @default.
- W2236679049 cites W2091543131 @default.
- W2236679049 cites W2092155461 @default.
- W2236679049 cites W2093461295 @default.
- W2236679049 cites W2096280264 @default.
- W2236679049 cites W2096390211 @default.
- W2236679049 cites W2104293075 @default.
- W2236679049 cites W2132958456 @default.
- W2236679049 cites W2136429139 @default.
- W2236679049 cites W2152110189 @default.
- W2236679049 cites W2163402335 @default.
- W2236679049 cites W2168476587 @default.
- W2236679049 cites W2170075593 @default.
- W2236679049 cites W2185433393 @default.
- W2236679049 cites W2295247981 @default.
- W2236679049 cites W4244647765 @default.
- W2236679049 cites W4244666018 @default.
- W2236679049 cites W4251144546 @default.
- W2236679049 cites W4253274980 @default.
- W2236679049 cites W4376596386 @default.
- W2236679049 cites W4376596483 @default.
- W2236679049 cites W85367440 @default.
- W2236679049 doi "https://doi.org/10.1038/srep12537" @default.
- W2236679049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4517395" @default.
- W2236679049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26219087" @default.
- W2236679049 hasPublicationYear "2015" @default.
- W2236679049 type Work @default.
- W2236679049 sameAs 2236679049 @default.
- W2236679049 citedByCount "32" @default.
- W2236679049 countsByYear W22366790492015 @default.
- W2236679049 countsByYear W22366790492016 @default.
- W2236679049 countsByYear W22366790492017 @default.
- W2236679049 countsByYear W22366790492018 @default.
- W2236679049 countsByYear W22366790492019 @default.
- W2236679049 countsByYear W22366790492020 @default.
- W2236679049 countsByYear W22366790492021 @default.
- W2236679049 countsByYear W22366790492022 @default.
- W2236679049 countsByYear W22366790492023 @default.
- W2236679049 crossrefType "journal-article" @default.
- W2236679049 hasAuthorship W2236679049A5031087323 @default.
- W2236679049 hasAuthorship W2236679049A5037149734 @default.
- W2236679049 hasAuthorship W2236679049A5040796037 @default.
- W2236679049 hasAuthorship W2236679049A5056182768 @default.
- W2236679049 hasAuthorship W2236679049A5062578726 @default.
- W2236679049 hasAuthorship W2236679049A5065791157 @default.
- W2236679049 hasAuthorship W2236679049A5076820743 @default.
- W2236679049 hasAuthorship W2236679049A5086960835 @default.
- W2236679049 hasAuthorship W2236679049A5090963306 @default.
- W2236679049 hasBestOaLocation W22366790491 @default.
- W2236679049 hasConcept C118131993 @default.
- W2236679049 hasConcept C126322002 @default.
- W2236679049 hasConcept C134018914 @default.
- W2236679049 hasConcept C142724271 @default.
- W2236679049 hasConcept C204787440 @default.
- W2236679049 hasConcept C207865475 @default.