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• W2236708035 abstract "The process by which pluripotent cells incorporate into host embryos is of interest to investigate cell potency and cell fate decisions. Previous studies suggest that only a minority of the embryonic stem cell (ESC) inoculum contributes to the adult chimaera. How incoming cells are chosen for integration or elimination remains unclear. By comparing a heterogeneous mix of undifferentiated and differentiating ESCs (serum/LIF) with more homogeneous undifferentiated culture (2i/LIF), we examine the role of cellular heterogeneity in this process. Time-lapse ex vivo imaging revealed a drastic elimination of serum/LIF ESCs during early development in comparison with 2i/LIF ESCs. Using a fluorescent reporter for naive pluripotency (Rex1-GFP), we established that the acutely eliminated serum/LIF ESCs had started to differentiate. The rejected cells were apparently killed by apoptosis. We conclude that a selection process exists by which unwanted differentiating cells are eliminated from the embryo. However, occasional Rex1(-) cells were able to integrate. Upregulation of Rex1 occurred in a proportion of these cells, reflecting the potential of the embryonic environment to expedite diversion from differentiation priming to enhance the developing embryonic epiblast." @default.
• W2236708035 created "2016-06-24" @default.
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• W2236708035 date "2015-01-01" @default.
• W2236708035 modified "2023-09-25" @default.
• W2236708035 title "Selection and dynamics of embryonic stem cell integration into early mouse embryos" @default.
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• W2236708035 doi "https://doi.org/10.1242/dev.124602" @default.
• W2236708035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4725202" @default.
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• W2236708035 hasPublicationYear "2015" @default.
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