FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2236726106> ?p ?o ?g. }

• W2236726106 endingPage "505" @default.
• W2236726106 startingPage "495" @default.
• W2236726106 abstract "Cardiac fibrosis is a major cause of heart failure. MicroRNAs (miRs) are important epigenetic regulators of cardiac function and cardiovascular diseases, including cardiac fibrosis. This study aimed to explore the role of miR-503 and its mechanisms in regulating cardiac fibrosis. miR-503 was found up-regulated in the mouse LV tissues subjected to transverse aortic constriction (TAC) and in neonatal cardiac fibroblasts (CFs) cultured with Angiotension II. The role of miR-503 in regulating CF cell proliferation and/or collagen production in mice neonatal CFs were determined using an MTT assay and RT-PCR respectively. Forced expression of miR-503 increased the cellular proliferation and collagen production in mice neonatal CFs. The effects were abrogated by cotransfection with AMO-503 (a specific inhibitor of miR-503). Injection of antagomiR-503 elevated cardiac function and inhibited the expression of connective tissue growth factor (CTGF) and transforming growth factor (TGF)-β in the TAC mice. Additional analysis revealed that Apelin-13 is a direct target of miR-503, as the overexpression of miR-503 decreased the protein and mRNA expression levels of Apelin-13. In the CFs with pre-treatment of AngII, we transfected AMO-503 into the cells treated with siRNA-APLN. siRNA-APLN abolished the effects of AMO-503 on the production of collagen I and III and the expression of TGF-β and CTGF. Furthermore, pre-treatment of CFs with Apelin-13 (1-100 nmol/l) inhibited angiotensin II-mediated collagen production and activation of CTGF and TGF-β. So we conclude that miR-503 promotes cardiac fibrosis via miR-503-Apelin-13-TGF-β-CTGF-collagen production pathway. Thus, miR-503 is a promising therapeutic target for reducing cardiac fibrosis." @default.
• W2236726106 created "2016-06-24" @default.
• W2236726106 creator A5011480715 @default.
• W2236726106 creator A5020553004 @default.
• W2236726106 creator A5024257236 @default.
• W2236726106 creator A5025295019 @default.
• W2236726106 creator A5028636270 @default.
• W2236726106 creator A5030666690 @default.
• W2236726106 creator A5033684035 @default.
• W2236726106 creator A5039997538 @default.
• W2236726106 creator A5040983782 @default.
• W2236726106 creator A5064161818 @default.
• W2236726106 creator A5077455454 @default.
• W2236726106 creator A5082834847 @default.
• W2236726106 date "2016-01-12" @default.
• W2236726106 modified "2023-10-16" @default.
• W2236726106 title "Micro <scp>RNA</scp> ‐503 promotes angiotensin II‐induced cardiac fibrosis by targeting Apelin‐13" @default.
• W2236726106 cites W1987351546 @default.
• W2236726106 cites W1992342469 @default.
• W2236726106 cites W1992389076 @default.
• W2236726106 cites W1996345315 @default.
• W2236726106 cites W1999943920 @default.
• W2236726106 cites W2002925464 @default.
• W2236726106 cites W2009269457 @default.
• W2236726106 cites W2014900267 @default.
• W2236726106 cites W2022547103 @default.
• W2236726106 cites W2023560350 @default.
• W2236726106 cites W2039081508 @default.
• W2236726106 cites W2042150160 @default.
• W2236726106 cites W2047078419 @default.
• W2236726106 cites W2051403674 @default.
• W2236726106 cites W2056869732 @default.
• W2236726106 cites W2060660919 @default.
• W2236726106 cites W2063242845 @default.
• W2236726106 cites W2072079310 @default.
• W2236726106 cites W2075798014 @default.
• W2236726106 cites W2078239070 @default.
• W2236726106 cites W2080696342 @default.
• W2236726106 cites W2084660313 @default.
• W2236726106 cites W2087107619 @default.
• W2236726106 cites W2097837136 @default.
• W2236726106 cites W2112849743 @default.
• W2236726106 cites W2116323280 @default.
• W2236726106 cites W2125809598 @default.
• W2236726106 cites W2129328611 @default.
• W2236726106 cites W2132093971 @default.
• W2236726106 cites W2144385056 @default.
• W2236726106 cites W2153513086 @default.
• W2236726106 cites W2169414490 @default.
• W2236726106 cites W2170906847 @default.
• W2236726106 cites W2699220065 @default.
• W2236726106 doi "https://doi.org/10.1111/jcmm.12754" @default.
• W2236726106 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4759464" @default.
• W2236726106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26756969" @default.
• W2236726106 hasPublicationYear "2016" @default.
• W2236726106 type Work @default.
• W2236726106 sameAs 2236726106 @default.
• W2236726106 citedByCount "66" @default.
• W2236726106 countsByYear W22367261062016 @default.
• W2236726106 countsByYear W22367261062017 @default.
• W2236726106 countsByYear W22367261062018 @default.
• W2236726106 countsByYear W22367261062019 @default.
• W2236726106 countsByYear W22367261062020 @default.
• W2236726106 countsByYear W22367261062021 @default.
• W2236726106 countsByYear W22367261062022 @default.
• W2236726106 countsByYear W22367261062023 @default.
• W2236726106 crossrefType "journal-article" @default.
• W2236726106 hasAuthorship W2236726106A5011480715 @default.
• W2236726106 hasAuthorship W2236726106A5020553004 @default.
• W2236726106 hasAuthorship W2236726106A5024257236 @default.
• W2236726106 hasAuthorship W2236726106A5025295019 @default.
• W2236726106 hasAuthorship W2236726106A5028636270 @default.
• W2236726106 hasAuthorship W2236726106A5030666690 @default.
• W2236726106 hasAuthorship W2236726106A5033684035 @default.
• W2236726106 hasAuthorship W2236726106A5039997538 @default.
• W2236726106 hasAuthorship W2236726106A5040983782 @default.
• W2236726106 hasAuthorship W2236726106A5064161818 @default.
• W2236726106 hasAuthorship W2236726106A5077455454 @default.
• W2236726106 hasAuthorship W2236726106A5082834847 @default.
• W2236726106 hasBestOaLocation W22367261061 @default.
• W2236726106 hasConcept C104317684 @default.
• W2236726106 hasConcept C111566952 @default.
• W2236726106 hasConcept C118131993 @default.
• W2236726106 hasConcept C119056186 @default.
• W2236726106 hasConcept C126322002 @default.
• W2236726106 hasConcept C127561419 @default.
• W2236726106 hasConcept C134018914 @default.
• W2236726106 hasConcept C145059251 @default.
• W2236726106 hasConcept C170493617 @default.
• W2236726106 hasConcept C185592680 @default.
• W2236726106 hasConcept C2775960820 @default.
• W2236726106 hasConcept C2777420927 @default.
• W2236726106 hasConcept C2778198053 @default.
• W2236726106 hasConcept C2779546753 @default.
• W2236726106 hasConcept C2780559512 @default.
• W2236726106 hasConcept C2780631158 @default.
• W2236726106 hasConcept C2908929049 @default.
• W2236726106 hasConcept C55493867 @default.

• next