Matches in SemOpenAlex for { <https://semopenalex.org/work/W2237101098> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2237101098 endingPage "5" @default.
- W2237101098 startingPage "532" @default.
- W2237101098 abstract "To investigate the prognostic value of thrombocytopenia in patients with primary myelodysplastic syndromes (MDS).Four hundred and nineteen primary MDS patients were retrospectively analyzed. Kaplan-Meier method, Log-rank test and COX regression model were used to evaluate factors that influence the prognosis.Two hundred and fifty-six cases (61.1%) had thrombocytopenia (PLT < 100×10(9)/L), one hundred and three cases (24.6%) had severe thrombocytopenia (PLT < 30×10(9)/L). Overall survival (OS) tended to shorten along with the decreasing of platelet count. Univariate analysis indicated that PL < 30×10(9)/L, MCV ≤ 95 fl, LDH ≥ 300 U/L, lymphocyte-like micromegakaryocyte, nucleated RBC PAS positive, IPSS cytogenetic intermediate- and poor-risk were all related with poor prognosis. Moreover, the prognosis of patients with RCMD, RAEB-Ior RAEB-IIwas poorer than that of the other subgroups. Among these parameters, PLT < 30×10(9)/L, MCV ≤ 95 fl, IPSS cytogenetic intermediate- and poor-risk group and RCMD, RAEB-I and RAEB-II had independent prognostic significance in multivariate analysis. Modified WPSS prognostic model was proposed by adopting PLT, MCV, chromosomal karyotype and WHO classification. The OS of patients with low risk, intermediate-1 risk, intermediate-2 risk and high risk were 59, 28, 14 and 4 months, respectively, and there was a statistically significant difference between the groups (P < 0.05).Severe thrombocytopenia indicated unfavorable prognosis, in combination with MCV, chromosomal karyotype and WHO classification, a modified WPSS prognostic model was proposed and worked well for prognostic indication in patients with MDS." @default.
- W2237101098 created "2016-06-24" @default.
- W2237101098 creator A5005650392 @default.
- W2237101098 creator A5010776860 @default.
- W2237101098 creator A5011020214 @default.
- W2237101098 creator A5016326991 @default.
- W2237101098 creator A5020573943 @default.
- W2237101098 creator A5025110659 @default.
- W2237101098 creator A5034950332 @default.
- W2237101098 creator A5059062052 @default.
- W2237101098 creator A5062416906 @default.
- W2237101098 creator A5070907703 @default.
- W2237101098 date "2012-07-01" @default.
- W2237101098 modified "2023-09-24" @default.
- W2237101098 title "[A preliminary study of prognostic value of thrombocytopenia in patients with primary myelodysplastic syndromes]." @default.
- W2237101098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22967412" @default.
- W2237101098 hasPublicationYear "2012" @default.
- W2237101098 type Work @default.
- W2237101098 sameAs 2237101098 @default.
- W2237101098 citedByCount "1" @default.
- W2237101098 countsByYear W22371010982015 @default.
- W2237101098 crossrefType "journal-article" @default.
- W2237101098 hasAuthorship W2237101098A5005650392 @default.
- W2237101098 hasAuthorship W2237101098A5010776860 @default.
- W2237101098 hasAuthorship W2237101098A5011020214 @default.
- W2237101098 hasAuthorship W2237101098A5016326991 @default.
- W2237101098 hasAuthorship W2237101098A5020573943 @default.
- W2237101098 hasAuthorship W2237101098A5025110659 @default.
- W2237101098 hasAuthorship W2237101098A5034950332 @default.
- W2237101098 hasAuthorship W2237101098A5059062052 @default.
- W2237101098 hasAuthorship W2237101098A5062416906 @default.
- W2237101098 hasAuthorship W2237101098A5070907703 @default.
- W2237101098 hasConcept C10515644 @default.
- W2237101098 hasConcept C126322002 @default.
- W2237101098 hasConcept C143998085 @default.
- W2237101098 hasConcept C144301174 @default.
- W2237101098 hasConcept C2780007613 @default.
- W2237101098 hasConcept C2780240888 @default.
- W2237101098 hasConcept C2780817109 @default.
- W2237101098 hasConcept C38180746 @default.
- W2237101098 hasConcept C50382708 @default.
- W2237101098 hasConcept C71924100 @default.
- W2237101098 hasConcept C90924648 @default.
- W2237101098 hasConceptScore W2237101098C10515644 @default.
- W2237101098 hasConceptScore W2237101098C126322002 @default.
- W2237101098 hasConceptScore W2237101098C143998085 @default.
- W2237101098 hasConceptScore W2237101098C144301174 @default.
- W2237101098 hasConceptScore W2237101098C2780007613 @default.
- W2237101098 hasConceptScore W2237101098C2780240888 @default.
- W2237101098 hasConceptScore W2237101098C2780817109 @default.
- W2237101098 hasConceptScore W2237101098C38180746 @default.
- W2237101098 hasConceptScore W2237101098C50382708 @default.
- W2237101098 hasConceptScore W2237101098C71924100 @default.
- W2237101098 hasConceptScore W2237101098C90924648 @default.
- W2237101098 hasIssue "7" @default.
- W2237101098 hasLocation W22371010981 @default.
- W2237101098 hasOpenAccess W2237101098 @default.
- W2237101098 hasPrimaryLocation W22371010981 @default.
- W2237101098 hasRelatedWork W121813311 @default.
- W2237101098 hasRelatedWork W1998259048 @default.
- W2237101098 hasRelatedWork W2053375584 @default.
- W2237101098 hasRelatedWork W2199740746 @default.
- W2237101098 hasRelatedWork W2361700749 @default.
- W2237101098 hasRelatedWork W2388119532 @default.
- W2237101098 hasRelatedWork W2530463927 @default.
- W2237101098 hasRelatedWork W2983005728 @default.
- W2237101098 hasRelatedWork W3018143780 @default.
- W2237101098 hasRelatedWork W4237137053 @default.
- W2237101098 hasVolume "33" @default.
- W2237101098 isParatext "false" @default.
- W2237101098 isRetracted "false" @default.
- W2237101098 magId "2237101098" @default.
- W2237101098 workType "article" @default.