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• W2237131799 endingPage "135" @default.
• W2237131799 startingPage "130" @default.
• W2237131799 abstract "Highly sensitive detection of proteins, especially those associated with cancers, is essential to biomedical research as well as clinical diagnosis. In this work, a simple and novel one-two-three signal amplification surface-enhanced Raman scattering (SERS) method for the detection of protein is fabricated by using label-free aptamer and dual-primer self-generation. Platelet-derived growth factor B-chain (PDGF-BB) is selected as the model protein. The one–two–three cascade DNA amplification means one target-aptamer binding event, two hairpin DNA switches and three DNA amplification reactions. This strategy possesses some remarkable features compared to conventional signal amplification methods: (i) A smart probe including a label-free aptamer is fabricated, for suitable hybridization without hindering the affinity of the aptamer toward its target. (ii) Using the unique structure switch of the aptamer and cooperator, a one–two–three working mode is developed to amplify the SERS signal. The amplification efficiency is enhanced. Given the unique and attractive characteristics, a simple and universal strategy is designed to accomplish ultrasensitive detection of proteins. The detection limit of PDGF-BB via SERS detection is 0.42 pM, with the linear range from 1.0×10−12 M to 10−8 M. It is potentially universal because the aptamer can be easily designed for biomolecules whose aptamers undergo similar conformational changes." @default.
• W2237131799 created "2016-06-24" @default.
• W2237131799 creator A5024946149 @default.
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• W2237131799 date "2016-05-01" @default.
• W2237131799 modified "2023-10-15" @default.
• W2237131799 title "Dual-primer self-generation SERS signal amplification assay for PDGF-BB using label-free aptamer" @default.
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• W2237131799 doi "https://doi.org/10.1016/j.bios.2015.11.090" @default.
• W2237131799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26703991" @default.
• W2237131799 hasPublicationYear "2016" @default.
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