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- W2237221810 abstract "Background and Aims: Long-term exposure to opiates induces physical dependence. The neurobiological mechanisms of these phenomena are not completely clear. Objective: The aim of this study was to evaluate the effect of intracerebroventricular (icv) administration of antagonist of A2a receptores on morphine withdrawal syndrome in male rat. Methods: Male wistar rats (200-240 g) were selected ( n=6) randomly and divided into seven groups. Morphine sulphate (daily 10mg/kg) diluted in water which distilled twice per day and injected daily by Insulin syringe 1ml as IP injection. Selective antagonist of A2a receptor or SCH-58261) 40, 80, 160 µg /5 µl/Rat) was diluted in 0.9% saline normal and injected as ICV by Hamilton syring. We considered 2 control groups one of which received morphine (daily morphine 10mg/kg IP + 0.9% saline normal ICV) and the other took morphine (daily 10mg/kg IP). Total volume of injection was 5 µl per rat which was injected with the rate of 5 µl/min. On ninth day, an hour after the last dose of morphine, at first, Selective antagonist of A2a receptor or SCH-58261) 40, 80, 160 µg 0/5 µl/Rat) that was diluted in 0.9% saline normal, injected as ICV by Hamilton syring. So aftere 3minut, naloxone (4 mg/kg’ ip) injected and the withdrawal signs (Jumping, Rearing, Genital Grooming, Abdomen Writhing and Wet Dog Shake) were recorded for 60 minutes. Results showed that pretreatment intracerebroventricular (icv) administration of SCH-58261) 40, 80, 160 µg /5 µl/Rat) evidently reduced all morphine-induced withdrawal symptoms (Jumping, Rearing, Genital Grooming, Abdomen Writhing and Wet Dog Shake). Using SCH-58261 alone didnt have any interaction or effect on withdrawal symptoms and none of the tests had any difference with saline normal. Conclusions: In conclusion we found that central injection of SCH-58261 decreased the morphine withdrawal symptoms." @default.
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- W2237221810 date "2012-09-01" @default.
- W2237221810 modified "2023-09-28" @default.
- W2237221810 title "The effect of A2a receptors antagonist on morphin withdrawal syndrome" @default.
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