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- W2237233419 abstract "Homeostatic regulation has been detected in many of the interactions between neurons and their targets, both effectors and other neurons. This chapter discusses this regulation in the nervous system. The regulation consists of a wide variety of negative feedback loops that can be categorized into local versus multisynaptic, synthesis-modulating versus release-modulating, and rapid versus slow. The chapter focuses on the implications of homeostasis of cell–cell interactions for the response to neuronal injury—in particular, the one that is associated with Parkinson's disease. For this study, rats are treated with neurotoxin 6-hydroxydopamine to produce a selective loss of dopamine neurons within the brain. The chapter discusses neuroregulatory deficits and their implications. Deficits in the ability to invoke compensations may exist in circumstances such as senescence, leading to accelerated rates of behavioral decline." @default.
- W2237233419 created "2016-06-24" @default.
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- W2237233419 date "1994-01-01" @default.
- W2237233419 modified "2023-10-03" @default.
- W2237233419 title "Chapter 15 Chemical transmission in the brain: homeostatic regulation and its functional implications" @default.
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- W2237233419 doi "https://doi.org/10.1016/s0079-6123(08)60776-1" @default.
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