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- W2237271051 abstract "Publisher Summary This chapter describes the role of neutral serine proteases in the mechanism of tumor cell lysis by human natural killer (NK) cells. NK cells comprise the key lymphoid effector cell subpopulation involved in natural cell-mediated immunity against primary and metastatic tumors. A number of studies have probed the biochemistry of the NK lytic mechanism, and studied the role of lysosomal enzymes, cellular hydrolases, and phospholipases and phospholipid methylation. The role of neutral serine proteases in tumor cell lysis has also been examined relative to the mechanism of cytolytic, activated macrophages, and it appears that tumor cell lysis mediated by macrophages is dependent, to some extent, on the secretion of neutral serine proteases. It appears that the ability of macrophages to bind to tumor cells and to secrete a cytolytic protease are independent functions, each of which are required for macrophage mediated lysis, and it has also been reported that the macrophage cytolytic protease interacts with hydrogen peroxide in a synergistic fashion in the cytolytic mechanism of this effector cell. A role for neutral serine proteases have also been suggested for the mechanism of K-cell killing in antibody-dependent cell-mediated cytotoxicity." @default.
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- W2237271051 date "1982-01-01" @default.
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- W2237271051 title "THE ROLE OF NEUTRAL SERINE PROTEASES IN THE MECHANISM OF TUMOR CELL LYSIS BY HUMAN NATURAL KILLER CELLS" @default.
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- W2237271051 doi "https://doi.org/10.1016/b978-0-12-341360-4.50139-6" @default.
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