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• W2237323103 abstract "Metabolic engineering is generally focused on static optimization of cells to maximize production of a desired product, though recently dynamic metabolic engineering has explored how metabolic programs can be varied over time to improve titer. However, these are not the only types of applications where metabolic engineering could make a significant impact. Here, we discuss a new conceptual framework, termed precision metabolic engineering, involving the design and engineering of systems that make different products in response to different signals. Rather than focusing on maximizing titer, these types of applications typically have three hallmarks: sensing signals that determine the desired metabolic target, completely directing metabolic flux in response to those signals, and producing sharp responses at specific signal thresholds. In this review, we will first discuss and provide examples of precision metabolic engineering. We will then discuss each of these hallmarks and identify which existing metabolic engineering methods can be applied to accomplish those tasks, as well as some of their shortcomings. Ultimately, precise control of metabolic systems has the potential to enable a host of new metabolic engineering and synthetic biology applications for any problem where flexibility of response to an external signal could be useful." @default.
• W2237323103 created "2016-06-24" @default.
• W2237323103 creator A5042481093 @default.
• W2237323103 creator A5057433738 @default.
• W2237323103 creator A5073347089 @default.
• W2237323103 date "2015-09-01" @default.
• W2237323103 modified "2023-10-14" @default.
• W2237323103 title "Precision metabolic engineering: The design of responsive, selective, and controllable metabolic systems" @default.
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• W2237323103 doi "https://doi.org/10.1016/j.ymben.2015.06.011" @default.
• W2237323103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4770000" @default.
• W2237323103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26189665" @default.
• W2237323103 hasPublicationYear "2015" @default.
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