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- W2237410683 abstract "Oral iron salts are widely prescribed for a variety of medical uses. Accidental overdoses has caused serious pathological consequences, especially in young children. Because iron is absorbed most efficiently when it is in the ferrous form, most oral preparations consist of a ferrous salt. Many preparations additionally contain ascorbic acid in order to maintain the iron in the reduced state. Ferrous ions in solution are readily oxidized by molecular oxygen, and can generate reactive products, including .OH. In this study, the authors demonstrate that intragastric instillation of a ferrous salt and ascorbic acid in rats produces .OH. .OH was detected by its reaction with intragastric 2-keto-4-methylthiobutyric acid to yield ethylene gas. Animals were placed into sealed rebreathing chambers and chamber ethylene was measured by gas chromatography. The authors studied a dose range of 10-100 mg ferrous sulfate (7H20) per 250 g rat. In experiments conducted in vitro, ascorbate had a biphasic action, increasing the yield of ethylene at low concentrations, but suppressing the yield at higher concentrations. Almost complete inhibition of product formation by catalase in vitro shows the involvement of hydrogen peroxide as an intermediate. The authors suggest that .OH a formed in vivo via a Fenton reaction betweenmore » ferrous ions and generated hydrogen peroxide, and that .OH may be responsible, in part, for damage to the GI tract by the oral iron.« less" @default.
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- W2237410683 date "1986-05-01" @default.
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- W2237410683 title "Hydroxyl radicals (. OH) and the toxicity of oral iron" @default.
- W2237410683 hasPublicationYear "1986" @default.
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