FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2237444995> ?p ?o ?g. }

• W2237444995 endingPage "925" @default.
• W2237444995 startingPage "921" @default.
• W2237444995 abstract "All the steroidal anti-inflammatory drugs currently available are glucocorticoids. The desired anti-inflammatory activities of glucocorticoids frequently are accompanied by adverse side effects, notably glycogenic activities and profound immunosuppression, that can limit clinical use. We recently identified 16-epiestriol, a naturally occurring steroid, as exhibiting significant anti-inflammatory activity without glycogenic activity. In the present study, we compared the effects of 16-epiestriol and hydrocortisone on the capacity of murine splenocytes to produce interferon-γ (IFN-γ). We injected young adult male BDF1 mice once with 20 mg/kg hydrocortisone or 20, 5, or 1 mg/kg 16-epiestriol and 4 h later harvested the splenocytes. Flow cytometric analysis confirmed that 16-epiestriol did not alter the number of CD3+ T cells in the spleen. In contrast to the suppressive effects of hydrocortisone, none of the 16-epiestriol concentrations inhibited concanavalin A-stimulated IFN-γ production by spleen cells, as determined by ELISA. Incubating spleen cells from untreated mice in concentrations of 16-epiestriol ranging from 1 mg/ml to 100 pg/ml did not alter profiles of IFN-γ production, in contrast to the suppressive dose-response effects of hydrocortisone. Collectively, these results support the contention that 16-epiestriol may be a clinically useful safe anti-inflammatory steroid without profound immunosuppressive activities." @default.
• W2237444995 created "2016-06-24" @default.
• W2237444995 creator A5004311186 @default.
• W2237444995 creator A5008342329 @default.
• W2237444995 creator A5029498575 @default.
• W2237444995 creator A5033990106 @default.
• W2237444995 creator A5048153320 @default.
• W2237444995 creator A5074334937 @default.
• W2237444995 creator A5082263512 @default.
• W2237444995 creator A5088290102 @default.
• W2237444995 date "1998-11-01" @default.
• W2237444995 modified "2023-10-18" @default.
• W2237444995 title "16-Epiestriol, a Novel Anti-Inflammatory Nonglycogenic Steroid, Does Not Inhibit IFN-γ Production by Murine Splenocytes" @default.
• W2237444995 cites W1481256029 @default.
• W2237444995 cites W1637312528 @default.
• W2237444995 cites W1850835571 @default.
• W2237444995 cites W1966616589 @default.
• W2237444995 cites W1985162445 @default.
• W2237444995 cites W1985839335 @default.
• W2237444995 cites W2047997516 @default.
• W2237444995 cites W2050099015 @default.
• W2237444995 cites W2064788322 @default.
• W2237444995 cites W2073993963 @default.
• W2237444995 cites W2080042419 @default.
• W2237444995 cites W2080556693 @default.
• W2237444995 cites W2100586808 @default.
• W2237444995 cites W2118442033 @default.
• W2237444995 cites W2175322775 @default.
• W2237444995 cites W2339948487 @default.
• W2237444995 cites W2412879644 @default.
• W2237444995 cites W4313313341 @default.
• W2237444995 doi "https://doi.org/10.1089/jir.1998.18.921" @default.
• W2237444995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9858313" @default.
• W2237444995 hasPublicationYear "1998" @default.
• W2237444995 type Work @default.
• W2237444995 sameAs 2237444995 @default.
• W2237444995 citedByCount "1" @default.
• W2237444995 countsByYear W22374449952013 @default.
• W2237444995 crossrefType "journal-article" @default.
• W2237444995 hasAuthorship W2237444995A5004311186 @default.
• W2237444995 hasAuthorship W2237444995A5008342329 @default.
• W2237444995 hasAuthorship W2237444995A5029498575 @default.
• W2237444995 hasAuthorship W2237444995A5033990106 @default.
• W2237444995 hasAuthorship W2237444995A5048153320 @default.
• W2237444995 hasAuthorship W2237444995A5074334937 @default.
• W2237444995 hasAuthorship W2237444995A5082263512 @default.
• W2237444995 hasAuthorship W2237444995A5088290102 @default.
• W2237444995 hasConcept C126322002 @default.
• W2237444995 hasConcept C134018914 @default.
• W2237444995 hasConcept C185592680 @default.
• W2237444995 hasConcept C189976730 @default.
• W2237444995 hasConcept C19869320 @default.
• W2237444995 hasConcept C202751555 @default.
• W2237444995 hasConcept C203014093 @default.
• W2237444995 hasConcept C2778690821 @default.
• W2237444995 hasConcept C2778709874 @default.
• W2237444995 hasConcept C2780252810 @default.
• W2237444995 hasConcept C2780902042 @default.
• W2237444995 hasConcept C2780931953 @default.
• W2237444995 hasConcept C55493867 @default.
• W2237444995 hasConcept C71315377 @default.
• W2237444995 hasConcept C71924100 @default.
• W2237444995 hasConcept C86803240 @default.
• W2237444995 hasConcept C98274493 @default.
• W2237444995 hasConceptScore W2237444995C126322002 @default.
• W2237444995 hasConceptScore W2237444995C134018914 @default.
• W2237444995 hasConceptScore W2237444995C185592680 @default.
• W2237444995 hasConceptScore W2237444995C189976730 @default.
• W2237444995 hasConceptScore W2237444995C19869320 @default.
• W2237444995 hasConceptScore W2237444995C202751555 @default.
• W2237444995 hasConceptScore W2237444995C203014093 @default.
• W2237444995 hasConceptScore W2237444995C2778690821 @default.
• W2237444995 hasConceptScore W2237444995C2778709874 @default.
• W2237444995 hasConceptScore W2237444995C2780252810 @default.
• W2237444995 hasConceptScore W2237444995C2780902042 @default.
• W2237444995 hasConceptScore W2237444995C2780931953 @default.
• W2237444995 hasConceptScore W2237444995C55493867 @default.
• W2237444995 hasConceptScore W2237444995C71315377 @default.
• W2237444995 hasConceptScore W2237444995C71924100 @default.
• W2237444995 hasConceptScore W2237444995C86803240 @default.
• W2237444995 hasConceptScore W2237444995C98274493 @default.
• W2237444995 hasIssue "11" @default.
• W2237444995 hasLocation W22374449951 @default.
• W2237444995 hasLocation W22374449952 @default.
• W2237444995 hasOpenAccess W2237444995 @default.
• W2237444995 hasPrimaryLocation W22374449951 @default.
• W2237444995 hasRelatedWork W1965997842 @default.
• W2237444995 hasRelatedWork W2002435184 @default.
• W2237444995 hasRelatedWork W2005909524 @default.
• W2237444995 hasRelatedWork W2016059890 @default.
• W2237444995 hasRelatedWork W2030022983 @default.
• W2237444995 hasRelatedWork W2055666671 @default.
• W2237444995 hasRelatedWork W2077059349 @default.
• W2237444995 hasRelatedWork W2159220770 @default.
• W2237444995 hasRelatedWork W2237444995 @default.
• W2237444995 hasRelatedWork W3200647722 @default.
• W2237444995 hasVolume "18" @default.
• W2237444995 isParatext "false" @default.

• next