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• W2237456462 abstract "Genome defense likely evolved to curtail the spread of transposable elements and invading viruses. A combination of effective defense mechanisms has been shown to limit colonization of the Neurospora crassa genome by transposable elements. A novel DNA transposon named Sly1-1 was discovered in the genome of the most widely used laboratory wild-type strain FGSC 2489 (OR74A). Meiotic silencing by unpaired DNA, also simply called meiotic silencing, prevents the expression of regions of the genome that are unpaired during karyogamy. This mechanism is posttranscriptional and is proposed to involve the production of small RNA, so-called masiRNAs, by proteins homologous to those involved in RNA interference-silencing pathways in animals, fungi, and plants. Here, we demonstrate production of small RNAs when Sly1-1 was unpaired in a cross between two wild-type strains. These small RNAs are dependent on SAD-1, an RNA-dependent RNA polymerase necessary for meiotic silencing. We present the first case of endogenously produced masiRNA from a novel N. crassa DNA transposable element." @default.
• W2237456462 created "2016-06-24" @default.
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• W2237456462 creator A5067544674 @default.
• W2237456462 creator A5067761628 @default.
• W2237456462 date "2015-10-01" @default.
• W2237456462 modified "2023-10-12" @default.
• W2237456462 title "Endogenous Small RNA Mediates Meiotic Silencing of a Novel DNA Transposon" @default.
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• W2237456462 doi "https://doi.org/10.1534/g3.115.017921" @default.
• W2237456462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4592977" @default.
• W2237456462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26109355" @default.
• W2237456462 hasPublicationYear "2015" @default.
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