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- W2237465345 abstract "Forty 20-day-old female Kunming mice were divided randomly into 3 treatment groups and 1 control group with 10 of each groups.The 3 treatment groups were injected abdominaly with 10,20 and 40 mg of lead acetate per kilogram of body weight for 2 days respectively,and the control group injected with the same volume of normal saline as the 3 treatment groups.The apoptosis rates of granulosa cells were detected by the TdT-mediated dUTP-biotin nick end labeling (TUNEL) and preparation of paraffin section on days 1 and 3 post-injection respectively,in order to investigate the change of lead acetate on the ovarian structure and apoptosis of granulose cells mice.The results indicated that the normal ovarian structure was changed throught effect of lead acetate,meanwhile the apoptosis of granulosa cells were accelerated,and the apoptosis rates of ovarian granulosa cells in every poisoning group increased significantly(P0.01)with relation to the increase of lead acetate dosage and time,compared with the control group.It is concluded that the lead acetate is harmful to ovarian,inducing the apoptosis of mouse ovarian granulosa cells with being dependent on the dose and time." @default.
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- W2237465345 date "2010-01-01" @default.
- W2237465345 modified "2023-09-22" @default.
- W2237465345 title "Effect of lead acetate on ovarian structure and ovarian granulosa cells apoptosis in mice." @default.
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