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- W2237466937 abstract "Purpose: In some inherited connective tissue diseases with involving of the cardiovascular system, e.g. Marfan syndrome has been reported early impairment of LV function, which has been described as Marfan-related cardiomyopathy. Our aim was to evaluate the LV function in young adults with mitral valve prolapse (MVP) without significant mitral regurgitation using two-dimensional strain imaging and the possible role of transforming growth factor-β (TGF-β) pathway in its deterioration. Methods: We studied 78 asymptomatic young subjects (mean age 19.7±1.6, 72% male) with MVP in comparison with 80 sex- and age-matched healthy subjects. Longitudinal strain and strain rate (SR) were determined from three apical views, using spackle tracking (Vivid 7 Dimension, EchoPAC’08) with grey-scale frame rate 50-55/sec. Concentrations of TGF-β1 and β2 in serum were determined by enzyme-linked immunosorbent assay using a test system Human Platinum ELISA. Results: During the k-means clustering we have identified two cluster..." @default.
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- W2237466937 date "2012-11-20" @default.
- W2237466937 modified "2023-09-27" @default.
- W2237466937 title "Abstract 9459: Mitral Valve Prolapse-Related Cardiomyopathy" @default.
- W2237466937 hasPublicationYear "2012" @default.
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