FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2237811559> ?p ?o ?g. }

• W2237811559 endingPage "287" @default.
• W2237811559 startingPage "283" @default.
• W2237811559 abstract "To explore the protective effect and its molecular mechanism of apoptosis signal-regulating kinase 1 (ASK1) inhibitor (GS-459679) on acetaminophen-induced liver injury in mice.The model of liver injury was established by administration of acetaminophen (APAP) (300 mg/kg, i.p.) on C57BL/6 mice. Forty-eight male C57BL/6 mice were randomly divided into four groups, consisting of control group, GS group (GS-459679, 30 mg/kg, i.p.), APAP-induced group, and GS combined with APAP-induced group. For GS combined with APAP-induced group, mice were treated with GS 30 min prior to administration of APAP. After mice were euthanized at 6 h or 12 h, respectively, serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were analyzed, and mRNA levels of TNF-α, IL-6 and IL-1β were tested. The activity of glutathione (GSH), oxidized GSH (GSSG) and malondialdehyde were quantified. In addition, ASK1, P-ASK1, JNK and P-JNK protein levels were tested in all groups.The ASK1 and P-ASK1 levels were up-regulated in APAP-induced group. Compared to the control group, serum levels of ALT and AST, and mRNA levels of TNF-α, IL-6 and IL-1β were increased in APAP-induced group. Meanwhile, the levels of MAD and GSSG, and the ratio of GSSG/GSH were higher and the JNK was activatedin APAP-induced group compared with that in control group. However, compared to APAP-induced group, GS combined with APAP-induced group displayed a decrease of protein expression levels of ASK1, P-ASK1 and P-JNK, a reduction of serum levels of ALT and AST, a decrease in TNF-α, IL-6 and IL-1β mRNA levels, and a low ration of GSSG/GSH.GS-459679 treatment effectively down-regulates ASK1 and P-ASK1 expression. Addition of GS-459679 decreases the generation of liver metabolites and inflammatory factors, reduces oxidative stress reaction, inhibits JNK activation, and then protects the responsiveness to APAP-induced liver injury." @default.
• W2237811559 created "2016-06-24" @default.
• W2237811559 creator A5023504231 @default.
• W2237811559 creator A5031979935 @default.
• W2237811559 creator A5050927196 @default.
• W2237811559 creator A5054228072 @default.
• W2237811559 creator A5060020008 @default.
• W2237811559 creator A5066752763 @default.
• W2237811559 creator A5091083546 @default.
• W2237811559 date "2016-03-01" @default.
• W2237811559 modified "2023-09-26" @default.
• W2237811559 title "Protective effect of apoptosis signal-regulating kinase 1 inhibitor against mice liver injury" @default.
• W2237811559 cites W1537971445 @default.
• W2237811559 cites W1983576933 @default.
• W2237811559 cites W1997878364 @default.
• W2237811559 cites W2003405892 @default.
• W2237811559 cites W2016409720 @default.
• W2237811559 cites W2016554175 @default.
• W2237811559 cites W2021600983 @default.
• W2237811559 cites W2021766187 @default.
• W2237811559 cites W2026239829 @default.
• W2237811559 cites W2028026620 @default.
• W2237811559 cites W2050542278 @default.
• W2237811559 cites W2063032227 @default.
• W2237811559 cites W2074545478 @default.
• W2237811559 cites W2075000148 @default.
• W2237811559 cites W2079350327 @default.
• W2237811559 cites W2100903885 @default.
• W2237811559 cites W2112144522 @default.
• W2237811559 cites W2129070184 @default.
• W2237811559 doi "https://doi.org/10.1016/j.apjtm.2016.01.029" @default.
• W2237811559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26972403" @default.
• W2237811559 hasPublicationYear "2016" @default.
• W2237811559 type Work @default.
• W2237811559 sameAs 2237811559 @default.
• W2237811559 citedByCount "10" @default.
• W2237811559 countsByYear W22378115592017 @default.
• W2237811559 countsByYear W22378115592019 @default.
• W2237811559 countsByYear W22378115592020 @default.
• W2237811559 countsByYear W22378115592021 @default.
• W2237811559 countsByYear W22378115592022 @default.
• W2237811559 crossrefType "journal-article" @default.
• W2237811559 hasAuthorship W2237811559A5023504231 @default.
• W2237811559 hasAuthorship W2237811559A5031979935 @default.
• W2237811559 hasAuthorship W2237811559A5050927196 @default.
• W2237811559 hasAuthorship W2237811559A5054228072 @default.
• W2237811559 hasAuthorship W2237811559A5060020008 @default.
• W2237811559 hasAuthorship W2237811559A5066752763 @default.
• W2237811559 hasAuthorship W2237811559A5091083546 @default.
• W2237811559 hasBestOaLocation W22378115591 @default.
• W2237811559 hasConcept C126322002 @default.
• W2237811559 hasConcept C134018914 @default.
• W2237811559 hasConcept C181199279 @default.
• W2237811559 hasConcept C184235292 @default.
• W2237811559 hasConcept C185592680 @default.
• W2237811559 hasConcept C190283241 @default.
• W2237811559 hasConcept C202751555 @default.
• W2237811559 hasConcept C2776151105 @default.
• W2237811559 hasConcept C2776200302 @default.
• W2237811559 hasConcept C2776637226 @default.
• W2237811559 hasConcept C2778401633 @default.
• W2237811559 hasConcept C2778722691 @default.
• W2237811559 hasConcept C538909803 @default.
• W2237811559 hasConcept C55493867 @default.
• W2237811559 hasConcept C71924100 @default.
• W2237811559 hasConcept C98274493 @default.
• W2237811559 hasConceptScore W2237811559C126322002 @default.
• W2237811559 hasConceptScore W2237811559C134018914 @default.
• W2237811559 hasConceptScore W2237811559C181199279 @default.
• W2237811559 hasConceptScore W2237811559C184235292 @default.
• W2237811559 hasConceptScore W2237811559C185592680 @default.
• W2237811559 hasConceptScore W2237811559C190283241 @default.
• W2237811559 hasConceptScore W2237811559C202751555 @default.
• W2237811559 hasConceptScore W2237811559C2776151105 @default.
• W2237811559 hasConceptScore W2237811559C2776200302 @default.
• W2237811559 hasConceptScore W2237811559C2776637226 @default.
• W2237811559 hasConceptScore W2237811559C2778401633 @default.
• W2237811559 hasConceptScore W2237811559C2778722691 @default.
• W2237811559 hasConceptScore W2237811559C538909803 @default.
• W2237811559 hasConceptScore W2237811559C55493867 @default.
• W2237811559 hasConceptScore W2237811559C71924100 @default.
• W2237811559 hasConceptScore W2237811559C98274493 @default.
• W2237811559 hasIssue "3" @default.
• W2237811559 hasLocation W22378115591 @default.
• W2237811559 hasLocation W22378115592 @default.
• W2237811559 hasOpenAccess W2237811559 @default.
• W2237811559 hasPrimaryLocation W22378115591 @default.
• W2237811559 hasRelatedWork W2028896927 @default.
• W2237811559 hasRelatedWork W2070656560 @default.
• W2237811559 hasRelatedWork W2094423915 @default.
• W2237811559 hasRelatedWork W2365322489 @default.
• W2237811559 hasRelatedWork W2409784700 @default.
• W2237811559 hasRelatedWork W2958136580 @default.
• W2237811559 hasRelatedWork W3003588602 @default.
• W2237811559 hasRelatedWork W3006758926 @default.
• W2237811559 hasRelatedWork W4315491170 @default.
• W2237811559 hasRelatedWork W2044231188 @default.
• W2237811559 hasVolume "9" @default.

• next