Matches in SemOpenAlex for { <https://semopenalex.org/work/W2237842945> ?p ?o ?g. }
- W2237842945 endingPage "97" @default.
- W2237842945 startingPage "87" @default.
- W2237842945 abstract "Lead exposure has been implicated in the impairment of synaptic plasticity in the hippocampal dentate gyrus (DG) areas of rats. However, whether the degradation of physiological properties is based on the morphological alteration of granule neurons in DG areas remains elusive. Here, we examined the dendritic branch extension and spine formation of granule neurons after lead exposure during development in rats. Dendritic morphology was studied using Golgi-Cox stain method, which was followed by Sholl analysis at postnatal days 14 and 21. Our results indicated that, for both ages, lead exposure significantly decreased the total dendritic length and spine density of granule neurons in the DG of the rat hippocampus. Further branch order analysis revealed that the decrease of dendritic length was observed only at the second branch order. Moreover, there were obvious deficits in the proportion and size of mushroom-type spines. These deficits in spine formation and maturity were accompanied by a decrease in Arc/Arg3.1 expression. Our present findings are the first to show that developmental lead exposure disturbs branch and spine formation in hippocampal DG areas. Arc/Arg3.1 may have a critical role in the disruption of neuronal morphology and synaptic plasticity in lead-exposed rats." @default.
- W2237842945 created "2016-06-24" @default.
- W2237842945 creator A5037378896 @default.
- W2237842945 creator A5037837951 @default.
- W2237842945 creator A5069761312 @default.
- W2237842945 date "2016-01-09" @default.
- W2237842945 modified "2023-10-17" @default.
- W2237842945 title "Effects of lead exposure on dendrite and spine development in hippocampal dentate gyrus areas of rats" @default.
- W2237842945 cites W1497271710 @default.
- W2237842945 cites W1642619469 @default.
- W2237842945 cites W1804267428 @default.
- W2237842945 cites W1963662934 @default.
- W2237842945 cites W1969692986 @default.
- W2237842945 cites W1978681592 @default.
- W2237842945 cites W1983284219 @default.
- W2237842945 cites W1986682398 @default.
- W2237842945 cites W1991291910 @default.
- W2237842945 cites W1993255478 @default.
- W2237842945 cites W1994823946 @default.
- W2237842945 cites W2002376394 @default.
- W2237842945 cites W2002446420 @default.
- W2237842945 cites W2013185658 @default.
- W2237842945 cites W2013836023 @default.
- W2237842945 cites W2023023592 @default.
- W2237842945 cites W2025956906 @default.
- W2237842945 cites W2028126096 @default.
- W2237842945 cites W2028314694 @default.
- W2237842945 cites W2033026245 @default.
- W2237842945 cites W2033159578 @default.
- W2237842945 cites W2036855091 @default.
- W2237842945 cites W2037265981 @default.
- W2237842945 cites W2039508969 @default.
- W2237842945 cites W2039969351 @default.
- W2237842945 cites W2043155477 @default.
- W2237842945 cites W2046909406 @default.
- W2237842945 cites W2049511526 @default.
- W2237842945 cites W2050865999 @default.
- W2237842945 cites W2060091703 @default.
- W2237842945 cites W2070864631 @default.
- W2237842945 cites W2077098114 @default.
- W2237842945 cites W2080428271 @default.
- W2237842945 cites W2084272791 @default.
- W2237842945 cites W2087824537 @default.
- W2237842945 cites W2088804493 @default.
- W2237842945 cites W2096912691 @default.
- W2237842945 cites W2097689792 @default.
- W2237842945 cites W2102973376 @default.
- W2237842945 cites W2104063302 @default.
- W2237842945 cites W2109950649 @default.
- W2237842945 cites W2110900924 @default.
- W2237842945 cites W2111155182 @default.
- W2237842945 cites W2111916392 @default.
- W2237842945 cites W2118069376 @default.
- W2237842945 cites W2122742180 @default.
- W2237842945 cites W2124683806 @default.
- W2237842945 cites W2129788044 @default.
- W2237842945 cites W2143418370 @default.
- W2237842945 cites W2155924534 @default.
- W2237842945 cites W2160769038 @default.
- W2237842945 cites W2163653612 @default.
- W2237842945 cites W2163679083 @default.
- W2237842945 cites W2167423431 @default.
- W2237842945 cites W2169865463 @default.
- W2237842945 cites W2169931542 @default.
- W2237842945 cites W2171074660 @default.
- W2237842945 cites W2217194615 @default.
- W2237842945 cites W3102058442 @default.
- W2237842945 cites W4240680252 @default.
- W2237842945 cites W4293029111 @default.
- W2237842945 doi "https://doi.org/10.1002/syn.21873" @default.
- W2237842945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26562488" @default.
- W2237842945 hasPublicationYear "2016" @default.
- W2237842945 type Work @default.
- W2237842945 sameAs 2237842945 @default.
- W2237842945 citedByCount "11" @default.
- W2237842945 countsByYear W22378429452017 @default.
- W2237842945 countsByYear W22378429452018 @default.
- W2237842945 countsByYear W22378429452020 @default.
- W2237842945 countsByYear W22378429452021 @default.
- W2237842945 countsByYear W22378429452022 @default.
- W2237842945 crossrefType "journal-article" @default.
- W2237842945 hasAuthorship W2237842945A5037378896 @default.
- W2237842945 hasAuthorship W2237842945A5037837951 @default.
- W2237842945 hasAuthorship W2237842945A5069761312 @default.
- W2237842945 hasConcept C148762608 @default.
- W2237842945 hasConcept C151730666 @default.
- W2237842945 hasConcept C169760540 @default.
- W2237842945 hasConcept C170493617 @default.
- W2237842945 hasConcept C174884520 @default.
- W2237842945 hasConcept C2524010 @default.
- W2237842945 hasConcept C2776464000 @default.
- W2237842945 hasConcept C33923547 @default.
- W2237842945 hasConcept C47611674 @default.
- W2237842945 hasConcept C49760210 @default.
- W2237842945 hasConcept C53250682 @default.
- W2237842945 hasConcept C55493867 @default.
- W2237842945 hasConcept C84248122 @default.
- W2237842945 hasConcept C86803240 @default.