FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2237895999> ?p ?o ?g. }

• W2237895999 abstract "Abstract Abstract 1078 Background: High BMI was recently identified as a new predictor of differentiation syndrome (DS) in a relatively small Tunisian series of 39 APL patients (pts) treated with ATRA and anthracycline based chemotherapy (Leuk Res 2010; 34: 545–547). We analyzed this parameter in a larger pt cohort included in European APL 93 and APL 2000 trials. Methods: Between 1993 and 2006, 1196 APL patients (pts) were included in APL93 and 2000 trials, of whom 1016 APL had BMI determination (524/576 in APL 93 and 492/620 in APL 2000). In both trials, induction treatment consisted of ATRA and DNR + AraC except in one arm of APL 2000 trial where standard risk pts (ie low and int risk using Sanz score) received no AraC. Chemotherapy (CT) was started on day 1 of ATRA treatment in high risk (Sanz score) pts and on day 3 of ATRA treatment in standard risk pts except in one arm of APL 93 where standard risk pts received CT after ATRA. In APL 2000 (but not APL 93) trial, high risk patients received prophylactic dexamethasone from day 1 of ATRA. Results: Median age was 45 years (range: 1–80). 260 (25.6%) pts were high risk, 420 (41.3%) int risk and 336 (33%) low risk. Median BMI was 25.8 kg/m2 (range: 10–38). CR was achieved in 92.9% pts. Overall incidence of DS (according to Frankel's criteria) was 23.3%. Prognostic factors associated with an increased risk of DS were baseline WBC > 3×109/l (p=0.03) (best cut-off for WBC count), inclusion in APL2000 trial (p 25.5 (p=0.031) and inclusion in APL 2000 (p=0.002) to be significantly associated with occurrence of DS whereas age, sex, baseline WBC and absence of AraC had no prognostic impact. In low risk pts, occurrence of DS was associated with a trend for shorter survival (p=0.051). BMI however lost its prognostic value for DS in intermediate and high risk pts. Conclusion: High BMI may be associated to a higher risk of DS, at least in low risk APL, suggesting that those patients may have to be monitored closely during induction treatment of APL. Disclosures: Fenaux: CELGENE, JANSSEN CILAG, AMGEN, ROCHE, GSK, NOVARTIS, MERCK, CEPHALON: Honoraria, Research Funding." @default.
• W2237895999 created "2016-06-24" @default.
• W2237895999 creator A5000436961 @default.
• W2237895999 creator A5003393586 @default.
• W2237895999 creator A5004066423 @default.
• W2237895999 creator A5007605254 @default.
• W2237895999 creator A5014800268 @default.
• W2237895999 creator A5014838075 @default.
• W2237895999 creator A5017435311 @default.
• W2237895999 creator A5019341062 @default.
• W2237895999 creator A5027227964 @default.
• W2237895999 creator A5034852239 @default.
• W2237895999 creator A5036207495 @default.
• W2237895999 creator A5051984074 @default.
• W2237895999 creator A5053031492 @default.
• W2237895999 creator A5054745373 @default.
• W2237895999 creator A5063236502 @default.
• W2237895999 creator A5065372182 @default.
• W2237895999 date "2010-12-21" @default.
• W2237895999 modified "2023-09-26" @default.
• W2237895999 title "High Body Mass Index (BMI) as a predictor of Differentiation Syndrome (DS) In Acute Promyelocytic Leukemia (APL)" @default.
• W2237895999 doi "https://doi.org/10.7490/f1000research.714.1" @default.
• W2237895999 hasPublicationYear "2010" @default.
• W2237895999 type Work @default.
• W2237895999 sameAs 2237895999 @default.
• W2237895999 citedByCount "0" @default.
• W2237895999 crossrefType "journal-article" @default.
• W2237895999 hasAuthorship W2237895999A5000436961 @default.
• W2237895999 hasAuthorship W2237895999A5003393586 @default.
• W2237895999 hasAuthorship W2237895999A5004066423 @default.
• W2237895999 hasAuthorship W2237895999A5007605254 @default.
• W2237895999 hasAuthorship W2237895999A5014800268 @default.
• W2237895999 hasAuthorship W2237895999A5014838075 @default.
• W2237895999 hasAuthorship W2237895999A5017435311 @default.
• W2237895999 hasAuthorship W2237895999A5019341062 @default.
• W2237895999 hasAuthorship W2237895999A5027227964 @default.
• W2237895999 hasAuthorship W2237895999A5034852239 @default.
• W2237895999 hasAuthorship W2237895999A5036207495 @default.
• W2237895999 hasAuthorship W2237895999A5051984074 @default.
• W2237895999 hasAuthorship W2237895999A5053031492 @default.
• W2237895999 hasAuthorship W2237895999A5054745373 @default.
• W2237895999 hasAuthorship W2237895999A5063236502 @default.
• W2237895999 hasAuthorship W2237895999A5065372182 @default.
• W2237895999 hasConcept C104317684 @default.
• W2237895999 hasConcept C120665830 @default.
• W2237895999 hasConcept C121332964 @default.
• W2237895999 hasConcept C121608353 @default.
• W2237895999 hasConcept C126322002 @default.
• W2237895999 hasConcept C141071460 @default.
• W2237895999 hasConcept C2776601000 @default.
• W2237895999 hasConcept C2776694085 @default.
• W2237895999 hasConcept C2776802502 @default.
• W2237895999 hasConcept C2780221984 @default.
• W2237895999 hasConcept C2781121885 @default.
• W2237895999 hasConcept C530470458 @default.
• W2237895999 hasConcept C55493867 @default.
• W2237895999 hasConcept C61511704 @default.
• W2237895999 hasConcept C71924100 @default.
• W2237895999 hasConcept C72563966 @default.
• W2237895999 hasConcept C86803240 @default.
• W2237895999 hasConcept C90924648 @default.
• W2237895999 hasConceptScore W2237895999C104317684 @default.
• W2237895999 hasConceptScore W2237895999C120665830 @default.
• W2237895999 hasConceptScore W2237895999C121332964 @default.
• W2237895999 hasConceptScore W2237895999C121608353 @default.
• W2237895999 hasConceptScore W2237895999C126322002 @default.
• W2237895999 hasConceptScore W2237895999C141071460 @default.
• W2237895999 hasConceptScore W2237895999C2776601000 @default.
• W2237895999 hasConceptScore W2237895999C2776694085 @default.
• W2237895999 hasConceptScore W2237895999C2776802502 @default.
• W2237895999 hasConceptScore W2237895999C2780221984 @default.
• W2237895999 hasConceptScore W2237895999C2781121885 @default.
• W2237895999 hasConceptScore W2237895999C530470458 @default.
• W2237895999 hasConceptScore W2237895999C55493867 @default.
• W2237895999 hasConceptScore W2237895999C61511704 @default.
• W2237895999 hasConceptScore W2237895999C71924100 @default.
• W2237895999 hasConceptScore W2237895999C72563966 @default.
• W2237895999 hasConceptScore W2237895999C86803240 @default.
• W2237895999 hasConceptScore W2237895999C90924648 @default.
• W2237895999 hasLocation W22378959991 @default.
• W2237895999 hasOpenAccess W2237895999 @default.
• W2237895999 hasPrimaryLocation W22378959991 @default.
• W2237895999 hasVolume "1" @default.
• W2237895999 isParatext "false" @default.
• W2237895999 isRetracted "false" @default.
• W2237895999 magId "2237895999" @default.
• W2237895999 workType "article" @default.