FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2237972574> ?p ?o ?g. }

• W2237972574 endingPage "17" @default.
• W2237972574 startingPage "9" @default.
• W2237972574 abstract "The binding of the anticonvulsant drug carbamazepine (CBZ) to human serum albumin, both without (dHSA) and in the presence of fatty acids (HSA) was studied in real time by capillary isoelectric focusing with whole column imaging detection (cIEF-WCID). Reaction mixtures at different CBZ:HSA and CBZ:dHSA molar ratios (0:1/25:1) were prepared in phosphate buffer saline (PBS) solution at a physiological pH (7.4), and incubated for 0-72h at 37°C in a water bath. Application of the cIEF-WCID method allowed for observations on the impact of increasing CBZ:serum albumin molar ratios on isoelectric point (pI) shifts, as well as changes in peak area and absorbance, which serve as evidence of structural alterations occurring in the protein in the presence of CBZ. The obtained cIEF-WCID results indicated that the dynamic process of complex formation is not dependent on incubation time. The presented work allowed for recognition of different types of interactions, as well as for the calculation of association constants that demonstrate the stability of the complex. This study was also designed to examine the possible impact of fatty acids (FAs) on protein stability and drug delivery in blood." @default.
• W2237972574 created "2016-06-24" @default.
• W2237972574 creator A5015518860 @default.
• W2237972574 creator A5022888470 @default.
• W2237972574 date "2016-08-01" @default.
• W2237972574 modified "2023-09-26" @default.
• W2237972574 title "The automatic use of capillary isoelectric focusing with whole column imaging detection for carbamazepine binding to human serum albumin" @default.
• W2237972574 cites W1515862194 @default.
• W2237972574 cites W1522964908 @default.
• W2237972574 cites W1546876446 @default.
• W2237972574 cites W1964900539 @default.
• W2237972574 cites W1966644851 @default.
• W2237972574 cites W1974428670 @default.
• W2237972574 cites W1974633955 @default.
• W2237972574 cites W1980078657 @default.
• W2237972574 cites W1981047925 @default.
• W2237972574 cites W1981792256 @default.
• W2237972574 cites W1994206549 @default.
• W2237972574 cites W2000589622 @default.
• W2237972574 cites W2010227296 @default.
• W2237972574 cites W2013886887 @default.
• W2237972574 cites W2021272496 @default.
• W2237972574 cites W2041780922 @default.
• W2237972574 cites W2045159210 @default.
• W2237972574 cites W2051440796 @default.
• W2237972574 cites W2059881573 @default.
• W2237972574 cites W2062032786 @default.
• W2237972574 cites W2063912727 @default.
• W2237972574 cites W2074193285 @default.
• W2237972574 cites W2075204962 @default.
• W2237972574 cites W2083961652 @default.
• W2237972574 cites W2084123824 @default.
• W2237972574 cites W2087510984 @default.
• W2237972574 cites W2088900329 @default.
• W2237972574 cites W2089658036 @default.
• W2237972574 cites W2090427843 @default.
• W2237972574 cites W2092670681 @default.
• W2237972574 cites W2095653057 @default.
• W2237972574 cites W2120741253 @default.
• W2237972574 cites W2155668124 @default.
• W2237972574 cites W2159994134 @default.
• W2237972574 cites W2160357565 @default.
• W2237972574 cites W2162916870 @default.
• W2237972574 doi "https://doi.org/10.1016/j.jpba.2016.01.023" @default.
• W2237972574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26809616" @default.
• W2237972574 hasPublicationYear "2016" @default.
• W2237972574 type Work @default.
• W2237972574 sameAs 2237972574 @default.
• W2237972574 citedByCount "3" @default.
• W2237972574 countsByYear W22379725742018 @default.
• W2237972574 countsByYear W22379725742021 @default.
• W2237972574 countsByYear W22379725742022 @default.
• W2237972574 crossrefType "journal-article" @default.
• W2237972574 hasAuthorship W2237972574A5015518860 @default.
• W2237972574 hasAuthorship W2237972574A5022888470 @default.
• W2237972574 hasBestOaLocation W22379725742 @default.
• W2237972574 hasConcept C165616093 @default.
• W2237972574 hasConcept C169760540 @default.
• W2237972574 hasConcept C181199279 @default.
• W2237972574 hasConcept C185592680 @default.
• W2237972574 hasConcept C2775858608 @default.
• W2237972574 hasConcept C2776125364 @default.
• W2237972574 hasConcept C2778186239 @default.
• W2237972574 hasConcept C2778597219 @default.
• W2237972574 hasConcept C2779253243 @default.
• W2237972574 hasConcept C43617362 @default.
• W2237972574 hasConcept C50476208 @default.
• W2237972574 hasConcept C55493867 @default.
• W2237972574 hasConcept C86803240 @default.
• W2237972574 hasConcept C96294017 @default.
• W2237972574 hasConcept C98015330 @default.
• W2237972574 hasConceptScore W2237972574C165616093 @default.
• W2237972574 hasConceptScore W2237972574C169760540 @default.
• W2237972574 hasConceptScore W2237972574C181199279 @default.
• W2237972574 hasConceptScore W2237972574C185592680 @default.
• W2237972574 hasConceptScore W2237972574C2775858608 @default.
• W2237972574 hasConceptScore W2237972574C2776125364 @default.
• W2237972574 hasConceptScore W2237972574C2778186239 @default.
• W2237972574 hasConceptScore W2237972574C2778597219 @default.
• W2237972574 hasConceptScore W2237972574C2779253243 @default.
• W2237972574 hasConceptScore W2237972574C43617362 @default.
• W2237972574 hasConceptScore W2237972574C50476208 @default.
• W2237972574 hasConceptScore W2237972574C55493867 @default.
• W2237972574 hasConceptScore W2237972574C86803240 @default.
• W2237972574 hasConceptScore W2237972574C96294017 @default.
• W2237972574 hasConceptScore W2237972574C98015330 @default.
• W2237972574 hasLocation W22379725741 @default.
• W2237972574 hasLocation W22379725742 @default.
• W2237972574 hasLocation W22379725743 @default.
• W2237972574 hasOpenAccess W2237972574 @default.
• W2237972574 hasPrimaryLocation W22379725741 @default.
• W2237972574 hasRelatedWork W1505231492 @default.
• W2237972574 hasRelatedWork W1576814845 @default.
• W2237972574 hasRelatedWork W1967483911 @default.
• W2237972574 hasRelatedWork W2076509471 @default.
• W2237972574 hasRelatedWork W2081258969 @default.
• W2237972574 hasRelatedWork W2151543787 @default.
• W2237972574 hasRelatedWork W2288115090 @default.

• next