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- W2238000649 abstract "In most high and middle income countries across the world, at least 1:4 women give birth by cesarean section. Rates of labour induction and augmentation are rising steeply; and in some countries up to 50% of laboring women and newborns are given antibiotics. Governments and international agencies are increasingly concerned about the clinical, economic and psychosocial effects of these interventions.There is emerging evidence that certain intrapartum and early neonatal interventions might affect the neonatal immune response in the longer term, and perhaps trans-generationally. Two theories lead the debate in this area. Those aligned with the hygiene (or 'Old Friends') hypothesis have examined the effect of gut microbiome colonization secondary to mode of birth and intrapartum/neonatal pharmacological interventions on immune response and epigenetic phenomena. Those working with the EPIIC (Epigenetic Impact of Childbirth) hypothesis are concerned with the effects of eustress and dys-stress on the epigenome, secondary to mode of birth and labour interventions. This paper examines the current and emerging findings relating to childbirth and atopic/autoimmune disease from the perspective of both theories, and proposes an alliance of research effort. This is likely to accelerate the discovery of important findings arising from both approaches, and to maximize the timely understanding of the longer-term consequences of childbirth practices." @default.
- W2238000649 created "2016-06-24" @default.
- W2238000649 creator A5002585794 @default.
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- W2238000649 creator A5021405296 @default.
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- W2238000649 date "2016-01-13" @default.
- W2238000649 modified "2023-10-10" @default.
- W2238000649 title "Childbirth and consequent atopic disease: emerging evidence on epigenetic effects based on the hygiene and EPIIC hypotheses" @default.
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- W2238000649 doi "https://doi.org/10.1186/s12884-015-0768-9" @default.
- W2238000649 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4712556" @default.
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- W2238000649 hasPublicationYear "2016" @default.
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