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• W2238018586 startingPage "1553" @default.
• W2238018586 abstract "A hallmark of active centromeres is the presence of the histone H3 variant CenH3 in the centromeric chromatin, which ensures faithful genome distribution at each cell division. A functional centromere can be inactivated, but the molecular mechanisms underlying the process of centromere inactivation remain largely unknown. Here, we describe the loss of CenH3 protein as part of a developmental program leading to the formation of the somatic nucleus in the eukaryote Paramecium. We identify two proteins whose depletion prevents developmental loss of CenH3: the domesticated transposase Pgm involved in the formation of DNA double strand cleavages and the Polycomb-like lysine methyltransferase Ezl1 necessary for trimethylation of histone H3 on lysine 9 and lysine 27. Taken together, our data support a model in which developmentally programmed centromere loss is caused by the elimination of DNA sequences associated with CenH3." @default.
• W2238018586 created "2016-06-24" @default.
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• W2238018586 date "2015-10-25" @default.
• W2238018586 modified "2023-10-10" @default.
• W2238018586 title "DNA deletion as a mechanism for developmentally programmed centromere loss" @default.
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• W2238018586 doi "https://doi.org/10.1093/nar/gkv1110" @default.
• W2238018586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4770206" @default.
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