FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2238181656> ?p ?o ?g. }

• W2238181656 endingPage "e0145832" @default.
• W2238181656 startingPage "e0145832" @default.
• W2238181656 abstract "Although our previous GWAS failed to identify SNPs associated with pulmonary function at the level of genomewide significance, it did show that the heritability for FEV1/FVC was 41.6% in a Japanese population, suggesting that the heritability of pulmonary function traits can be explained by the additive effects of multiple common SNPs. In addition, our previous study indicated that pulmonary function genes identified in previous GWASs in non-Japanese populations accounted for 4.3% to 12.0% of the entire estimated heritability of FEV1/FVC in a Japanese population. Therefore, given that many loci with individual weak effects may contribute to asthma risk, in this study, we created a quantitative score of genetic load based on 16 SNPs implicated in lower lung function in both Japanese and non-Japanese populations. This genetic risk score (GRS) for lower FEV1/FVC was consistently associated with the onset of asthma (P = 9.6 × 10−4) in 2 independent Japanese populations as well as with the onset of COPD (P = 0.042). Clustering of asthma patients based on GRS levels indicated that an increased GRS may be responsible for the development of a particular phenotype of asthma characterized by early onset, atopy, and severer airflow obstruction." @default.
• W2238181656 created "2016-06-24" @default.
• W2238181656 creator A5005183404 @default.
• W2238181656 creator A5010091637 @default.
• W2238181656 creator A5014676549 @default.
• W2238181656 creator A5025695892 @default.
• W2238181656 creator A5026942255 @default.
• W2238181656 creator A5038668801 @default.
• W2238181656 creator A5046657844 @default.
• W2238181656 creator A5047383533 @default.
• W2238181656 creator A5048903492 @default.
• W2238181656 creator A5056730917 @default.
• W2238181656 creator A5065562694 @default.
• W2238181656 creator A5066473285 @default.
• W2238181656 creator A5075577375 @default.
• W2238181656 date "2016-01-11" @default.
• W2238181656 modified "2023-09-23" @default.
• W2238181656 title "Role of Lung Function Genes in the Development of Asthma" @default.
• W2238181656 cites W2005334314 @default.
• W2238181656 cites W2010962160 @default.
• W2238181656 cites W2021085462 @default.
• W2238181656 cites W2021579290 @default.
• W2238181656 cites W2038934596 @default.
• W2238181656 cites W2043515584 @default.
• W2238181656 cites W2057630113 @default.
• W2238181656 cites W2070330568 @default.
• W2238181656 cites W2075278891 @default.
• W2238181656 cites W2083559141 @default.
• W2238181656 cites W2098184979 @default.
• W2238181656 cites W2099598799 @default.
• W2238181656 cites W2103038852 @default.
• W2238181656 cites W2104036976 @default.
• W2238181656 cites W2105130062 @default.
• W2238181656 cites W2107766358 @default.
• W2238181656 cites W2108338542 @default.
• W2238181656 cites W2111344085 @default.
• W2238181656 cites W2111679769 @default.
• W2238181656 cites W2120407239 @default.
• W2238181656 cites W2122819603 @default.
• W2238181656 cites W2144288460 @default.
• W2238181656 cites W2147628946 @default.
• W2238181656 cites W2148564836 @default.
• W2238181656 cites W2150035260 @default.
• W2238181656 cites W2153070821 @default.
• W2238181656 cites W2168850818 @default.
• W2238181656 cites W4300514609 @default.
• W2238181656 doi "https://doi.org/10.1371/journal.pone.0145832" @default.
• W2238181656 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4709100" @default.
• W2238181656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26752288" @default.
• W2238181656 hasPublicationYear "2016" @default.
• W2238181656 type Work @default.
• W2238181656 sameAs 2238181656 @default.
• W2238181656 citedByCount "12" @default.
• W2238181656 countsByYear W22381816562016 @default.
• W2238181656 countsByYear W22381816562017 @default.
• W2238181656 countsByYear W22381816562018 @default.
• W2238181656 countsByYear W22381816562020 @default.
• W2238181656 countsByYear W22381816562021 @default.
• W2238181656 countsByYear W22381816562022 @default.
• W2238181656 countsByYear W22381816562023 @default.
• W2238181656 crossrefType "journal-article" @default.
• W2238181656 hasAuthorship W2238181656A5005183404 @default.
• W2238181656 hasAuthorship W2238181656A5010091637 @default.
• W2238181656 hasAuthorship W2238181656A5014676549 @default.
• W2238181656 hasAuthorship W2238181656A5025695892 @default.
• W2238181656 hasAuthorship W2238181656A5026942255 @default.
• W2238181656 hasAuthorship W2238181656A5038668801 @default.
• W2238181656 hasAuthorship W2238181656A5046657844 @default.
• W2238181656 hasAuthorship W2238181656A5047383533 @default.
• W2238181656 hasAuthorship W2238181656A5048903492 @default.
• W2238181656 hasAuthorship W2238181656A5056730917 @default.
• W2238181656 hasAuthorship W2238181656A5065562694 @default.
• W2238181656 hasAuthorship W2238181656A5066473285 @default.
• W2238181656 hasAuthorship W2238181656A5075577375 @default.
• W2238181656 hasBestOaLocation W22381816561 @default.
• W2238181656 hasConcept C104317684 @default.
• W2238181656 hasConcept C106208931 @default.
• W2238181656 hasConcept C126322002 @default.
• W2238181656 hasConcept C135763542 @default.
• W2238181656 hasConcept C139275648 @default.
• W2238181656 hasConcept C153209595 @default.
• W2238181656 hasConcept C161890455 @default.
• W2238181656 hasConcept C186413461 @default.
• W2238181656 hasConcept C2776042228 @default.
• W2238181656 hasConcept C2776780178 @default.
• W2238181656 hasConcept C2777697326 @default.
• W2238181656 hasConcept C2777714996 @default.
• W2238181656 hasConcept C2908647359 @default.
• W2238181656 hasConcept C3018587741 @default.
• W2238181656 hasConcept C54355233 @default.
• W2238181656 hasConcept C71924100 @default.
• W2238181656 hasConcept C75603125 @default.
• W2238181656 hasConcept C86803240 @default.
• W2238181656 hasConcept C99454951 @default.
• W2238181656 hasConceptScore W2238181656C104317684 @default.
• W2238181656 hasConceptScore W2238181656C106208931 @default.
• W2238181656 hasConceptScore W2238181656C126322002 @default.
• W2238181656 hasConceptScore W2238181656C135763542 @default.

• next