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• W2238211597 endingPage "107" @default.
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• W2238211597 abstract "African-American adults are disproportionately affected by stress-related chronic conditions like high blood pressure (BP), and both environmental stress and genetic risk may play a role in its development.This study tested whether the dual risk of low neighborhood socioeconomic status (SES) and glucocorticoid genetic sensitivity interacted to predict waking cortisol and BP.Cross-sectional waking cortisol and BP were collected from 208 African-American adults who were participating in a follow-up visit as part of the Positive Action for Today's Health trial. Three single-nucleotide polymorphisms were genotyped, salivary cortisol samples were collected, and neighborhood SES was calculated using 2010 Census data.The sample was mostly female (65 %), with weight classified as overweight or obese (M BMI = 32.74, SD = 8.88) and a mean age of 55.64 (SD = 15.21). The gene-by-neighborhood SES interaction predicted cortisol (B = 0.235, p = .001, r (2) = .036), but not BP. For adults with high genetic sensitivity, waking cortisol was lower with lower SES but higher with higher SES (B = 0.87). Lower neighborhood SES was also related to higher systolic BP (B = -0.794, p = .028).Findings demonstrated an interaction whereby African-American adults with high genetic sensitivity had high levels of waking cortisol with higher neighborhood SES, and low levels with lower neighborhood SES. This moderation effect is consistent with a differential susceptibility gene-environment pattern, rather than a dual-risk pattern. These findings contribute to a growing body of evidence that demonstrates the importance of investigating complex gene-environment relations in order to better understand stress-related health disparities." @default.
• W2238211597 created "2016-06-24" @default.
• W2238211597 creator A5016537149 @default.
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• W2238211597 creator A5046953968 @default.
• W2238211597 creator A5053893637 @default.
• W2238211597 creator A5072805309 @default.
• W2238211597 date "2015-12-18" @default.
• W2238211597 modified "2023-10-01" @default.
• W2238211597 title "The Association of Neighborhood Gene-Environment Susceptibility with Cortisol and Blood Pressure in African-American Adults" @default.
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• W2238211597 doi "https://doi.org/10.1007/s12160-015-9737-9" @default.
• W2238211597 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5108625" @default.
• W2238211597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26685668" @default.
• W2238211597 hasPublicationYear "2015" @default.
• W2238211597 type Work @default.

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