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- W2238215052 abstract "The vaccinia virus I3L gene encodes a single-stranded DNA binding protein (SSB) that is essential for virus DNA replication and is conserved in all Chordopoxviruses. The I3 protein contains a negatively charged C-terminal tail that is a common feature of SSBs. Such acidic tails are critical for SSB-dependent replication, recombination and repair. We cloned and purified variants of the I3 protein, along with a homolog from molluscum contagiosum virus, and tested how the acidic tail affected DNA–protein interactions. Deleting the C terminus of I3 enhanced the affinity for single-stranded DNA cellulose and gel shift analyses showed that it also altered the migration of I3-DNA complexes in agarose gels. Microinjecting an antibody against I3 into vaccinia-infected cells also selectively inhibited virus replication. We suggest that this domain promotes cooperative binding of I3 to DNA in a way that would maintain an open DNA configuration around a replication site." @default.
- W2238215052 created "2016-06-24" @default.
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- W2238215052 date "2016-02-01" @default.
- W2238215052 modified "2023-10-02" @default.
- W2238215052 title "The acidic C-terminus of vaccinia virus I3 single-strand binding protein promotes proper assembly of DNA–protein complexes" @default.
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- W2238215052 doi "https://doi.org/10.1016/j.virol.2015.12.020" @default.
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