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- W2238236951 endingPage "318" @default.
- W2238236951 startingPage "277" @default.
- W2238236951 abstract "In 1958, Carlsson and collaborators (Carlsson et al. 1958) discovered that dopamine is present in high concentrations in the rat corpus striatum and is depleted by reserpine. Since the hypokinesia associated with reserpine administration was reversed by L-dopa, Carlsson (1959) postulated that dopamine is a neurotransmitter involved in extrapyramidal motor function. In 1960, Ehringer and Hornykiewicz found that the Parkinsonian brain contains reduced amounts of dopamine due to degeneration of dopaminergic neurons. These findings have led to the replacement therapy of Parkinson’s disease with L-dopa (Birkmayer and Hornykiewicz 1961; Barbeau et al. 1962; Cotzias et al. 1967) and by L-dopa plus peripheral decarboxylase inhibitors (Bartholini et al. 1967). Since then, investigations on the physiology and pharmacology of the dopaminergic systems have resulted in major progress in the understanding of the pathogenesis of neuropsychiatric disorders involving dopaminergic mechanisms. These include schizophrenia and extrapyramidal disorders." @default.
- W2238236951 created "2016-06-24" @default.
- W2238236951 creator A5056541056 @default.
- W2238236951 creator A5060441858 @default.
- W2238236951 creator A5065591303 @default.
- W2238236951 date "1989-01-01" @default.
- W2238236951 modified "2023-09-26" @default.
- W2238236951 title "Dopaminergic Neurons: Basic Aspects" @default.
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