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• W2238268214 startingPage "1648" @default.
• W2238268214 abstract "The P300/CBP-associated factor plays a central role in retroviral infection and cancer development, and the C-terminal bromodomain provides an opportunity for selective targeting. Here, we report several new classes of acetyl-lysine mimetic ligands ranging from mM to low micromolar affinity that were identified using fragment screening approaches. The binding modes of the most attractive fragments were determined using high resolution crystal structures providing chemical starting points and structural models for the development of potent and selective PCAF inhibitors." @default.
• W2238268214 created "2016-06-24" @default.
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• W2238268214 date "2016-01-13" @default.
• W2238268214 modified "2023-10-03" @default.
• W2238268214 title "Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain" @default.
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• W2238268214 doi "https://doi.org/10.1021/acs.jmedchem.5b01719" @default.
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