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- W2238278349 abstract "ABSTRACT ATP-dependent chromatin remodeling complexes are essential for transcription regulation, and yet it is unclear how these multisubunit complexes coordinate their activities to facilitate diverse transcriptional responses. In this study, we found that the conserved Arp5 and Ies6 subunits of the Saccharomyces cerevisiae INO80 chromatin-remodeler form an abundant and distinct subcomplex in vivo and stimulate INO80-mediated activity in vitro . Moreover, our genomic studies reveal that the relative occupancy of Arp5-Ies6 correlates with nucleosome positioning at transcriptional start sites and expression levels of >1,000 INO80-regulated genes. Notably, these genes are significantly enriched in energy metabolism pathways. Specifically, arp5 Δ, ies6 Δ, and ino80 Δ mutants demonstrate decreased expression of genes involved in glycolysis and increased expression of genes in the oxidative phosphorylation pathway. Deregulation of these metabolic pathways results in constitutively elevated mitochondrial potential and oxygen consumption. Our results illustrate the dynamic nature of the INO80 complex assembly and demonstrate for the first time that a chromatin remodeler regulates glycolytic and respiratory capacity, thereby maintaining metabolic stability." @default.
- W2238278349 created "2016-06-24" @default.
- W2238278349 creator A5004799122 @default.
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- W2238278349 date "2016-03-15" @default.
- W2238278349 modified "2023-10-15" @default.
- W2238278349 title "The INO80 Complex Requires the Arp5-Ies6 Subcomplex for Chromatin Remodeling and Metabolic Regulation" @default.
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- W2238278349 doi "https://doi.org/10.1128/mcb.00801-15" @default.
- W2238278349 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4810468" @default.
- W2238278349 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26755556" @default.
- W2238278349 hasPublicationYear "2016" @default.
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