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- W2238280045 abstract "Glucuronidation is an important phase II reaction catalyzed by the UDP-glucuronosyltransferases (UGTs), UGTs are enzymes involved in a number of metabolic processes, including phase II drug metabolism conjugation of endogenous compounds with glucuronic acid, such as bilirubin and estradiol with glucuronic acid, to form water-soluble conjugates for excretion; and detoxification of potential carcinogens. Clinicians need to be aware of the options available to them for irinotecan and hyperbilirubinemia genetic testing. When complying with the minimum FDA requirements for irinotecan dose adjustments by only testing to determine if the *28 allele is present, patients of African or Asian ancestry could potentially be put at increased risk for neutropenia with this drug. Many factors go into determining hyperbilirubinemia; having a comprehensive genetic test available to aid a physician in treatment options (UGT1A1 genetic based or not) provides the patient with the best clinical outcome. The UGT1A1 gene is a complex gene, not only in its design, with alternative splicing on the 5’ and 3’ end of the gene, but also because of the impact it has on genetic diseases and drug metabolism. In addition, the variations that have been reported (known star alleles) all have different frequencies depending on ethnicity. As a result, an allele (for example, *6) may have vast clinical significance in one ethnicity but is rarely observed in other populations. Only by continuing to investigate and research the gene in various populations can we further our understanding on the clinical significance and impact of UGT1A1." @default.
- W2238280045 created "2016-06-24" @default.
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- W2238280045 date "2010-01-01" @default.
- W2238280045 modified "2023-09-27" @default.
- W2238280045 title "UDP-Glucuronosyltransferase 1A1 and the Glucuronidation in Oncology Applications and Hyperbilirubinemia" @default.
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- W2238280045 doi "https://doi.org/10.1016/b978-0-12-369428-7.00033-1" @default.
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