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- W22382808 endingPage "160" @default.
- W22382808 startingPage "115" @default.
- W22382808 abstract "A substantial portion of metabolism involves transformation of phosphate esters, including pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and steroids, and phosphorylated proteins. Because the natural substrates bear one or more negative charges, drugs that target these enzymes generally must be charged as well, but small charged molecules can have difficulty traversing the cell membrane by means other than endocytosis. The resulting dichotomy has stimulated a great deal of effort to develop effective prodrugs, compounds that carry little or no charge to enable them to transit biological membranes, but able to release the parent drug once inside the target cell. This chapter presents recent studies on advances in prodrug forms, along with representative examples of their application to marketed and developmental drugs." @default.
- W22382808 created "2016-06-24" @default.
- W22382808 creator A5080031865 @default.
- W22382808 creator A5088029990 @default.
- W22382808 date "2014-01-01" @default.
- W22382808 modified "2023-10-01" @default.
- W22382808 title "Prodrugs of Phosphonates and Phosphates: Crossing the Membrane Barrier" @default.
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