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- W2238283456 abstract "6045 Background: We sought to review the experience of our center with the treatment of patients with locally advanced salivary gland cancers and identify prognostic factors of outcome. Methods: We reviewed records of patients with malignant salivary gland tumors registered within University of Pittsburgh databases from 1980–2006. Selection criteria included newly diagnosed stage III or IV disease treated with surgery followed by postoperative RT. Patients with early stage or distant metastatic disease, history of skin or other head and neck cancer, non-salivary gland pathology, history of immunosuppresion, or previous treatment were excluded. Parameters of interest included age, gender, stage, primary site, histologic type and pathologic features (grade, perineural invasion, extracapsular spread and positive margins), and treatment type. Results: Of 492 patients initially identified, 78 met the inclusion criteria. Characteristics were as follows: Male 42/female 36; median age 59 years (21–90); stage III, 41%; stage IV, 59%; N2 stage, 33%; N0–1, 67%. Primary site: parotid, 69%; submandibular, 8%; minor 23%. Histology: adenoid cystic carcinoma, 21%; salivary duct carcinoma, 22%; adenocarcinoma, 19%; mucoepidermoid carcinoma, 15%; carcinoma ex pleomorphic adenoma, 8%; acinic cell carcinoma, 6%; and other, 6%. 49% had positive margins and 64% perineural invasion. The median RT dose was 60 Gy; 13 pts received concurrent chemotherapy (10 with carboplatin). With a median follow-up of 3.9 years, the 3- and 5-year disease-free survival (DFS) was 70% and 52%, respectively; the 3- and 5-year overall survival was 71% and 58%, respectively. Primary site (others vs. minor salivary glands), stage (IV vs. III) and N stage (N2 vs. N0–1), and presence of perineural invasion were predictive of worse DFS in univariate analysis. On Cox-regression analysis, stage and site were independent predictors of DFS. Conclusions: The long-term outcome of patients with high-risk, locally advanced salivary gland cancers is unsatisfactory. Stage and primary site are important determinants of DFS. The addition of novel agents to postoperative RT should be explored in prospective clinical trials. No significant financial relationships to disclose." @default.
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- W2238283456 date "2008-05-20" @default.
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- W2238283456 title "Prognostic factors in patients with locally advanced salivary gland cancers treated with surgery and postoperative radiotherapy (RT)" @default.
- W2238283456 doi "https://doi.org/10.1200/jco.2008.26.15_suppl.6045" @default.
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