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- W2238283607 abstract "A prototype strain of herpes simplex virus type 2 (HG-52) replicated at 31 degrees C was avirulent when inoculated intracranially into mice. This property was not altered after serial passage of the agent at 31 degrees C, but the virus became virulent after passage at 37.5 degrees C. The selection was not merely for an agent which replicated more efficiently at the higher temperature, but for viruses with enhanced capacity to replicate in the brains of mice. Virulent descendants of plaque-purified avirulent stocks were obtained in each instance attempted." @default.
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- W2238283607 date "1983-08-01" @default.
- W2238283607 modified "2023-09-24" @default.
- W2238283607 title "Replication at body temperature selects a neurovirulent herpes simplex virus type 2" @default.
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- W2238283607 doi "https://doi.org/10.1128/iai.41.2.855-857.1983" @default.
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