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- W2238332807 abstract "The procedure described in this chapter provides the framework for directly studying transplacental passive/active molecular transport or metabolism, and the downstream consequences this might have for the developing fetus. By design, ex vivo and in vitro experiments are performed in an inherently dissimilar environment to those found in vivo. Accordingly, individual environmental and genetic aspects can be manipulated at will, affording researchers greater experimental control. Ultimately, the results obtained from ex vivo conditions can provide novel hypotheses that are testable in vivo. In comparison to the incredibly plastic nature of gestational conditions, both in terms of fetal development as well as maternal circulatory and metabolic changes, an ex vivo placental perfusion setup provides defined conditions and good temporal resolution. This procedure provides a low-cost, high-throughput assay for transplacental transfer of various pharmacological substances throughout gestation, as well as the framework for basic research on placental metabolism and the downstream effects on fetal development." @default.
- W2238332807 created "2016-06-24" @default.
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- W2238332807 date "2014-01-01" @default.
- W2238332807 modified "2023-10-16" @default.
- W2238332807 title "Ex vivo Perfusion of the Mouse Placenta for Maternal–Fetal Interaction Studies during Pregnancy" @default.
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- W2238332807 doi "https://doi.org/10.1016/b978-0-12-394445-0.00057-6" @default.
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