Matches in SemOpenAlex for { <https://semopenalex.org/work/W22383662> ?p ?o ?g. }
- W22383662 endingPage "389" @default.
- W22383662 startingPage "373" @default.
- W22383662 abstract "World-wide, many fetuses and infants are exposed to methylxanthines via maternal consumption of coffee and other beverages containing these substances. Methylxanthines (caffeine, theophylline and aminophylline) are also commonly used as a medication for apnea of prematurity. The metabolism of methylxanthines is impaired in pregnant women, fetuses and neonates, leading to accumulating levels thereof. Methylxanthines readily passes the placenta barrier and enters all tissues and thus may affect the fetus/newborn at any time during pregnancy or postnatal life, given that the effector systems are mature. At clinically relevant doses, the major effector system for methylxanthines is adenosine receptors. Animal studies suggest that adenosine receptors in the cardiovascular, respiratory and immune system are developed at birth, but that cerebral adenosine receptors are not fully functional. Furthermore animal studies have shown protective positive effects of methylxanthines in situations of hypoxia/ischemia in neonates. Similarly, a positive long-term effect on lung function and CNS development was found in human preterm infants treated with high doses of caffeine for apneas. There is now evidence that the overall benefits from methylxanthine therapy for apnea of prematurity outweigh potential short-term risks. On the other hand it is important to note that experimental studies have indicated that long-term effects of caffeine during pregnancy and postnatally may include altered behavior and altered respiratory control in the offspring, although there is currently no human data to support this. Some epidemiology studies have reported negative effects on pregnancy and perinatal outcomes related to maternal ingestion of high doses of caffeine, but the results are inconclusive. The evidence base for adverse effects of caffeine in first third of pregnancy are stronger than for later parts of pregnancy and there is currently insufficient evidence to advise women to restrict caffeine intake after the first trimester." @default.
- W22383662 created "2016-06-24" @default.
- W22383662 creator A5083653220 @default.
- W22383662 date "2010-08-19" @default.
- W22383662 modified "2023-10-14" @default.
- W22383662 title "Methylxanthines During Pregnancy and Early Postnatal Life" @default.
- W22383662 cites W1489310181 @default.
- W22383662 cites W1489750347 @default.
- W22383662 cites W1521659744 @default.
- W22383662 cites W1590738868 @default.
- W22383662 cites W1963830083 @default.
- W22383662 cites W1964337652 @default.
- W22383662 cites W1965813454 @default.
- W22383662 cites W1966612977 @default.
- W22383662 cites W1967945609 @default.
- W22383662 cites W1974957298 @default.
- W22383662 cites W1982398833 @default.
- W22383662 cites W1982970734 @default.
- W22383662 cites W1990113288 @default.
- W22383662 cites W1992553177 @default.
- W22383662 cites W1993363142 @default.
- W22383662 cites W1993379450 @default.
- W22383662 cites W1995941325 @default.
- W22383662 cites W1996021831 @default.
- W22383662 cites W1997358651 @default.
- W22383662 cites W1998161295 @default.
- W22383662 cites W1999541069 @default.
- W22383662 cites W2000725200 @default.
- W22383662 cites W2001420919 @default.
- W22383662 cites W2003353494 @default.
- W22383662 cites W2004041728 @default.
- W22383662 cites W2004832219 @default.
- W22383662 cites W2005610180 @default.
- W22383662 cites W2005645716 @default.
- W22383662 cites W2005985863 @default.
- W22383662 cites W2007469691 @default.
- W22383662 cites W2007998500 @default.
- W22383662 cites W2010158234 @default.
- W22383662 cites W2013407710 @default.
- W22383662 cites W2014737847 @default.
- W22383662 cites W2015729159 @default.
- W22383662 cites W2020633711 @default.
- W22383662 cites W2024837830 @default.
- W22383662 cites W2026337484 @default.
- W22383662 cites W2031339009 @default.
- W22383662 cites W2037912983 @default.
- W22383662 cites W2039720313 @default.
- W22383662 cites W2041292257 @default.
- W22383662 cites W2047069067 @default.
- W22383662 cites W2047158667 @default.
- W22383662 cites W2048800299 @default.
- W22383662 cites W2052531167 @default.
- W22383662 cites W2056385117 @default.
- W22383662 cites W2059729208 @default.
- W22383662 cites W2070308559 @default.
- W22383662 cites W2075412461 @default.
- W22383662 cites W2079283237 @default.
- W22383662 cites W2083336724 @default.
- W22383662 cites W2086111128 @default.
- W22383662 cites W2088115551 @default.
- W22383662 cites W2092811589 @default.
- W22383662 cites W2093330447 @default.
- W22383662 cites W2095394581 @default.
- W22383662 cites W2100786853 @default.
- W22383662 cites W2103853915 @default.
- W22383662 cites W2123141619 @default.
- W22383662 cites W2125473372 @default.
- W22383662 cites W2130249957 @default.
- W22383662 cites W2134391819 @default.
- W22383662 cites W2137630880 @default.
- W22383662 cites W2148737684 @default.
- W22383662 cites W2151610969 @default.
- W22383662 cites W2156976674 @default.
- W22383662 cites W2158075213 @default.
- W22383662 cites W2164147349 @default.
- W22383662 cites W2202090535 @default.
- W22383662 cites W2417938246 @default.
- W22383662 cites W4229871131 @default.
- W22383662 doi "https://doi.org/10.1007/978-3-642-13443-2_14" @default.
- W22383662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20859804" @default.
- W22383662 hasPublicationYear "2010" @default.
- W22383662 type Work @default.
- W22383662 sameAs 22383662 @default.
- W22383662 citedByCount "36" @default.
- W22383662 countsByYear W223836622012 @default.
- W22383662 countsByYear W223836622013 @default.
- W22383662 countsByYear W223836622014 @default.
- W22383662 countsByYear W223836622015 @default.
- W22383662 countsByYear W223836622016 @default.
- W22383662 countsByYear W223836622017 @default.
- W22383662 countsByYear W223836622018 @default.
- W22383662 countsByYear W223836622019 @default.
- W22383662 countsByYear W223836622020 @default.
- W22383662 countsByYear W223836622021 @default.
- W22383662 countsByYear W223836622022 @default.
- W22383662 countsByYear W223836622023 @default.
- W22383662 crossrefType "book-chapter" @default.
- W22383662 hasAuthorship W22383662A5083653220 @default.