FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2238366867> ?p ?o ?g. }

• W2238366867 endingPage "125" @default.
• W2238366867 startingPage "112" @default.
• W2238366867 abstract "Malignant gliomas especially glioblastoma (GBM) are poorly responsive to the current treatments. Cilengitide (CGT) is a cyclic pentapeptide that demonstrated efficacy for GBM treatment by targeting the integrins avβ3 and avβ5 over-expressed on GBM cells. However, clinical translation of this therapy has been limited by issues including fast blood clearance, high kidney and liver uptake, poor blood–brain barrier (BBB) penetration, low tumor specificity and rapid washout from tumors. In this study, these issues were tackled in an integrated manner using a multi-stage strategy combining ultrasound-targeted microbubble destruction (UTMD) with CGT nanotherapy. CGT nanoparticles (CGT-NP) prepared using gelatin and Poloxamer 188-grafted heparin copolymer demonstrated significant apoptotic and cytotoxic effects in C6 GBM cells. Biodistribution study in a rat GBM model demonstrated buildup of high CGT level in tumors subjected to CGT-NP + UTMD combined therapy. The tumor CGT level in these animals was increased over 3-fold, tumor retention of CGT prolonged and renal clearance significantly reduced when compared with free CGT with or without UTMD. CGT-NP + UTMD treatment was further shown to extend the median survival period from less than 20 days in the control and about 30 days in free CGT group to about 80 days. This was achieved with low CGT dosing level (2 mg/kg twice weekly). In situ monitoring of GFAP, Ki67, caspase-3, Beclin-1, and LC-3 in the tumor samples together with TUNEL assay, transmission electron microscope imaging and Western blot assay all demonstrated high apoptotic and autophagy activities induced by the combined therapy. In conclusion, this study has provided extensive preclinical data supporting the use of this combined therapy to overcome the limitations of standard CGT treatment of gliomas." @default.
• W2238366867 created "2016-06-24" @default.
• W2238366867 creator A5005262130 @default.
• W2238366867 creator A5017860687 @default.
• W2238366867 creator A5033779515 @default.
• W2238366867 creator A5037960195 @default.
• W2238366867 creator A5045648276 @default.
• W2238366867 creator A5049258884 @default.
• W2238366867 creator A5062742490 @default.
• W2238366867 creator A5065436197 @default.
• W2238366867 creator A5073427217 @default.
• W2238366867 creator A5074904348 @default.
• W2238366867 creator A5076512552 @default.
• W2238366867 creator A5080956749 @default.
• W2238366867 date "2016-02-01" @default.
• W2238366867 modified "2023-10-17" @default.
• W2238366867 title "Glioma-targeted therapy using Cilengitide nanoparticles combined with UTMD enhanced delivery" @default.
• W2238366867 cites W1501926866 @default.
• W2238366867 cites W1569304607 @default.
• W2238366867 cites W1785073076 @default.
• W2238366867 cites W1964130824 @default.
• W2238366867 cites W1965384612 @default.
• W2238366867 cites W1970683344 @default.
• W2238366867 cites W1974079063 @default.
• W2238366867 cites W1976970322 @default.
• W2238366867 cites W1989532943 @default.
• W2238366867 cites W1991623686 @default.
• W2238366867 cites W1992176533 @default.
• W2238366867 cites W1996901510 @default.
• W2238366867 cites W2014537537 @default.
• W2238366867 cites W2024072689 @default.
• W2238366867 cites W2028267884 @default.
• W2238366867 cites W2029091507 @default.
• W2238366867 cites W2034231369 @default.
• W2238366867 cites W2043234656 @default.
• W2238366867 cites W2065916354 @default.
• W2238366867 cites W2067612317 @default.
• W2238366867 cites W2070472280 @default.
• W2238366867 cites W2079022594 @default.
• W2238366867 cites W2080208032 @default.
• W2238366867 cites W2088659772 @default.
• W2238366867 cites W2093460275 @default.
• W2238366867 cites W2096642458 @default.
• W2238366867 cites W2098208110 @default.
• W2238366867 cites W2098507717 @default.
• W2238366867 cites W2101922439 @default.
• W2238366867 cites W2103816610 @default.
• W2238366867 cites W2108933679 @default.
• W2238366867 cites W2111348099 @default.
• W2238366867 cites W2113758972 @default.
• W2238366867 cites W2115362657 @default.
• W2238366867 cites W2120618889 @default.
• W2238366867 cites W2123218036 @default.
• W2238366867 cites W2125394569 @default.
• W2238366867 cites W2125541186 @default.
• W2238366867 cites W2130225202 @default.
• W2238366867 cites W2136471260 @default.
• W2238366867 cites W2139731575 @default.
• W2238366867 cites W2150456585 @default.
• W2238366867 cites W2162377653 @default.
• W2238366867 cites W2164138192 @default.
• W2238366867 cites W2167107456 @default.
• W2238366867 cites W2170383392 @default.
• W2238366867 doi "https://doi.org/10.1016/j.jconrel.2016.01.015" @default.
• W2238366867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26792571" @default.
• W2238366867 hasPublicationYear "2016" @default.
• W2238366867 type Work @default.
• W2238366867 sameAs 2238366867 @default.
• W2238366867 citedByCount "61" @default.
• W2238366867 countsByYear W22383668672016 @default.
• W2238366867 countsByYear W22383668672017 @default.
• W2238366867 countsByYear W22383668672018 @default.
• W2238366867 countsByYear W22383668672019 @default.
• W2238366867 countsByYear W22383668672020 @default.
• W2238366867 countsByYear W22383668672021 @default.
• W2238366867 countsByYear W22383668672022 @default.
• W2238366867 countsByYear W22383668672023 @default.
• W2238366867 crossrefType "journal-article" @default.
• W2238366867 hasAuthorship W2238366867A5005262130 @default.
• W2238366867 hasAuthorship W2238366867A5017860687 @default.
• W2238366867 hasAuthorship W2238366867A5033779515 @default.
• W2238366867 hasAuthorship W2238366867A5037960195 @default.
• W2238366867 hasAuthorship W2238366867A5045648276 @default.
• W2238366867 hasAuthorship W2238366867A5049258884 @default.
• W2238366867 hasAuthorship W2238366867A5062742490 @default.
• W2238366867 hasAuthorship W2238366867A5065436197 @default.
• W2238366867 hasAuthorship W2238366867A5073427217 @default.
• W2238366867 hasAuthorship W2238366867A5074904348 @default.
• W2238366867 hasAuthorship W2238366867A5076512552 @default.
• W2238366867 hasAuthorship W2238366867A5080956749 @default.
• W2238366867 hasConcept C112705442 @default.
• W2238366867 hasConcept C126322002 @default.
• W2238366867 hasConcept C185592680 @default.
• W2238366867 hasConcept C190283241 @default.
• W2238366867 hasConcept C202751555 @default.
• W2238366867 hasConcept C2777649898 @default.
• W2238366867 hasConcept C2777807558 @default.
• W2238366867 hasConcept C2778227246 @default.

• next