FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2238368487> ?p ?o ?g. }

• W2238368487 endingPage "233" @default.
• W2238368487 startingPage "220" @default.
• W2238368487 abstract "Introduction: Following a traumatic brain injury (TBI), the excessive release of proinflammatory cytokines is major cause of cerebral edema that can cause permanent neuronal loss. This study examined the changes in brain concentrations of proinflammatory cytokines IL-1, IL-6, TNF-α and TGF- after different doses of estrogen or progesterone treatment in brain-injured rats at 6 and 24 h post-injury. Methods: Adult female rats were divided into 14 groups, and underwent either bilateral ovariectomy (12 groups) or sham surgery (2 groups). The hormones or vehicle were given intraperitoneally 0.5 h after TBI. Moderate TBI was induced by Marmarou method in TBI or treatment groups and brain levels of proinflammatory cytokines were measured 6 and 24 h post-injury. Results: The results indicated that high dose of estrogen (E2) and low dose of progesterone (P1) increase brain levels of IL-1 6 h post-injury by 52.8% and 79.2%, respectively compared to the vehicle. By the 24 th h post-injury brain IL-1 level was reduced 27.5% and 27%, respectively compared to vehicle, when estrogen low dose (E1) and E2 were administered. Progesterone high dose treatment reduced brain level of IL-6 by 45.9% at 6 h post-injury and P1 treatment reduced IL-6 level by 20.5% at 24 h post-injury when compared to the vehicle. The brain TNF-α level was reduced by 72.5% by P2 at 6 h and 48.5% by E2 at 24 h post-injury, when compared to the vehicle. In addition, TGF- level seem to be increased by E1 up to 3.37 times at 24 h post-injury compared to the vehicle. Both doses of hormones showed increased levels of TGF- at 6 h post-injury, when compared to the vehicle. Conclusion: We conclude that progesterone and estrogen may change the levels of proinflammatory cytokines in the acute or delayed phases after TBI and this may be one of the mechanisms by which hormones reduce cerebral edema." @default.
• W2238368487 created "2016-06-24" @default.
• W2238368487 creator A5007804010 @default.
• W2238368487 creator A5008082559 @default.
• W2238368487 creator A5027638155 @default.
• W2238368487 creator A5063404883 @default.
• W2238368487 creator A5069845613 @default.
• W2238368487 creator A5088165195 @default.
• W2238368487 date "2010-10-10" @default.
• W2238368487 modified "2023-09-23" @default.
• W2238368487 title "Effect of Estrogen and Progesterone on Cytokines Levels at Different Time Intervals after Traumatic Brain Injury" @default.
• W2238368487 cites W1496877897 @default.
• W2238368487 cites W1504288624 @default.
• W2238368487 cites W1594364707 @default.
• W2238368487 cites W1603434131 @default.
• W2238368487 cites W161222424 @default.
• W2238368487 cites W1730467529 @default.
• W2238368487 cites W1862082420 @default.
• W2238368487 cites W1906318903 @default.
• W2238368487 cites W1966969529 @default.
• W2238368487 cites W1973094858 @default.
• W2238368487 cites W1973986558 @default.
• W2238368487 cites W1974915539 @default.
• W2238368487 cites W1987948730 @default.
• W2238368487 cites W1993887245 @default.
• W2238368487 cites W1998635342 @default.
• W2238368487 cites W2008458912 @default.
• W2238368487 cites W2016650346 @default.
• W2238368487 cites W2025604415 @default.
• W2238368487 cites W2027649064 @default.
• W2238368487 cites W2027829600 @default.
• W2238368487 cites W2030032536 @default.
• W2238368487 cites W2030628554 @default.
• W2238368487 cites W2033449172 @default.
• W2238368487 cites W2034775781 @default.
• W2238368487 cites W2049112657 @default.
• W2238368487 cites W2065518048 @default.
• W2238368487 cites W2066314160 @default.
• W2238368487 cites W2067487401 @default.
• W2238368487 cites W2075782105 @default.
• W2238368487 cites W2080644701 @default.
• W2238368487 cites W2082011784 @default.
• W2238368487 cites W2093281755 @default.
• W2238368487 cites W2094295748 @default.
• W2238368487 cites W2098029347 @default.
• W2238368487 cites W2102410705 @default.
• W2238368487 cites W2111152232 @default.
• W2238368487 cites W2111565797 @default.
• W2238368487 cites W2123389203 @default.
• W2238368487 cites W2125298896 @default.
• W2238368487 cites W2146677348 @default.
• W2238368487 cites W2162258317 @default.
• W2238368487 cites W2172287852 @default.
• W2238368487 cites W957686210 @default.
• W2238368487 hasPublicationYear "2010" @default.
• W2238368487 type Work @default.
• W2238368487 sameAs 2238368487 @default.
• W2238368487 citedByCount "0" @default.
• W2238368487 crossrefType "journal-article" @default.
• W2238368487 hasAuthorship W2238368487A5007804010 @default.
• W2238368487 hasAuthorship W2238368487A5008082559 @default.
• W2238368487 hasAuthorship W2238368487A5027638155 @default.
• W2238368487 hasAuthorship W2238368487A5063404883 @default.
• W2238368487 hasAuthorship W2238368487A5069845613 @default.
• W2238368487 hasAuthorship W2238368487A5088165195 @default.
• W2238368487 hasConcept C118552586 @default.
• W2238368487 hasConcept C126322002 @default.
• W2238368487 hasConcept C134018914 @default.
• W2238368487 hasConcept C164027704 @default.
• W2238368487 hasConcept C2776914184 @default.
• W2238368487 hasConcept C2777164284 @default.
• W2238368487 hasConcept C2781017439 @default.
• W2238368487 hasConcept C3019162651 @default.
• W2238368487 hasConcept C71315377 @default.
• W2238368487 hasConcept C71924100 @default.
• W2238368487 hasConceptScore W2238368487C118552586 @default.
• W2238368487 hasConceptScore W2238368487C126322002 @default.
• W2238368487 hasConceptScore W2238368487C134018914 @default.
• W2238368487 hasConceptScore W2238368487C164027704 @default.
• W2238368487 hasConceptScore W2238368487C2776914184 @default.
• W2238368487 hasConceptScore W2238368487C2777164284 @default.
• W2238368487 hasConceptScore W2238368487C2781017439 @default.
• W2238368487 hasConceptScore W2238368487C3019162651 @default.
• W2238368487 hasConceptScore W2238368487C71315377 @default.
• W2238368487 hasConceptScore W2238368487C71924100 @default.
• W2238368487 hasIssue "3" @default.
• W2238368487 hasLocation W22383684871 @default.
• W2238368487 hasOpenAccess W2238368487 @default.
• W2238368487 hasPrimaryLocation W22383684871 @default.
• W2238368487 hasRelatedWork W1958525259 @default.
• W2238368487 hasRelatedWork W2000521404 @default.
• W2238368487 hasRelatedWork W2057062377 @default.
• W2238368487 hasRelatedWork W2120159778 @default.
• W2238368487 hasRelatedWork W2282663187 @default.
• W2238368487 hasRelatedWork W2331416299 @default.
• W2238368487 hasRelatedWork W2353522596 @default.
• W2238368487 hasRelatedWork W2367432762 @default.
• W2238368487 hasRelatedWork W2367662246 @default.

• next