Matches in SemOpenAlex for { <https://semopenalex.org/work/W2238376240> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2238376240 startingPage "1731" @default.
- W2238376240 abstract "Background: Patients with COPD with chronic mucus hypersecretion (CMH) have a significantly increased FEV1 decline and a higher risk of hospitalization than those without CMH. Moreover, although individuals with CMH are more likely to be ex- or current smokers, so far it is unclear why some smokers develop CMH and others do not. A plausible explanation for this phenomenon would be a genetic predisposition.Methods: We performed a genome wide association study (GWAs) using the Nelson study (a population-based lung cancer screening study from Groningen and Utrecht, the Netherlands) including 717 subjects with and 1,795 without CMH, all ex or current heavy smokers (>20 pack years). Lung function results and information about sputum expectoration during the previous year were collected at the start of the study. To enhance power we added 590 blood bank controls. Genotyping data were analyzed using PLINK with adjustment for center (Groningen/Utrecht). We aimed to replicate the results by evaluating the top single nucleotide polymorphisms (SNPs) in 7 European cohorts contributing 487 cases and 1,118 controls.Results: We identified 77 SNPs associated with CMH with a p-value <10-4, of which 5 SNPs had a p-value <10-5. Meta-analysis of selected top SNPs in the initial and replication cohorts identified 3 SNPs with a p-value <10-6 and 3 with a p-value <10-5. Some genes close to these SNPs have been reported to be associated with epithelial changes.Conclusion: This study suggests that susceptibility to CMH is associated with genetic predisposition. To confirm these data replication will be extended to 3 additional cohorts." @default.
- W2238376240 created "2016-06-24" @default.
- W2238376240 creator A5003930458 @default.
- W2238376240 creator A5016743774 @default.
- W2238376240 creator A5017960622 @default.
- W2238376240 creator A5030603878 @default.
- W2238376240 creator A5037141001 @default.
- W2238376240 creator A5040458654 @default.
- W2238376240 creator A5041949240 @default.
- W2238376240 creator A5053144579 @default.
- W2238376240 creator A5072320602 @default.
- W2238376240 creator A5089844188 @default.
- W2238376240 date "2011-09-01" @default.
- W2238376240 modified "2023-09-23" @default.
- W2238376240 title "Susceptibility to chronic mucus hypersecretion: A genome-wide association study" @default.
- W2238376240 hasPublicationYear "2011" @default.
- W2238376240 type Work @default.
- W2238376240 sameAs 2238376240 @default.
- W2238376240 citedByCount "0" @default.
- W2238376240 crossrefType "journal-article" @default.
- W2238376240 hasAuthorship W2238376240A5003930458 @default.
- W2238376240 hasAuthorship W2238376240A5016743774 @default.
- W2238376240 hasAuthorship W2238376240A5017960622 @default.
- W2238376240 hasAuthorship W2238376240A5030603878 @default.
- W2238376240 hasAuthorship W2238376240A5037141001 @default.
- W2238376240 hasAuthorship W2238376240A5040458654 @default.
- W2238376240 hasAuthorship W2238376240A5041949240 @default.
- W2238376240 hasAuthorship W2238376240A5053144579 @default.
- W2238376240 hasAuthorship W2238376240A5072320602 @default.
- W2238376240 hasAuthorship W2238376240A5089844188 @default.
- W2238376240 hasConcept C104317684 @default.
- W2238376240 hasConcept C106208931 @default.
- W2238376240 hasConcept C126322002 @default.
- W2238376240 hasConcept C135763542 @default.
- W2238376240 hasConcept C139275648 @default.
- W2238376240 hasConcept C143998085 @default.
- W2238376240 hasConcept C153209595 @default.
- W2238376240 hasConcept C186413461 @default.
- W2238376240 hasConcept C2779134260 @default.
- W2238376240 hasConcept C2908647359 @default.
- W2238376240 hasConcept C31467283 @default.
- W2238376240 hasConcept C54355233 @default.
- W2238376240 hasConcept C67636389 @default.
- W2238376240 hasConcept C71924100 @default.
- W2238376240 hasConcept C86803240 @default.
- W2238376240 hasConcept C99454951 @default.
- W2238376240 hasConceptScore W2238376240C104317684 @default.
- W2238376240 hasConceptScore W2238376240C106208931 @default.
- W2238376240 hasConceptScore W2238376240C126322002 @default.
- W2238376240 hasConceptScore W2238376240C135763542 @default.
- W2238376240 hasConceptScore W2238376240C139275648 @default.
- W2238376240 hasConceptScore W2238376240C143998085 @default.
- W2238376240 hasConceptScore W2238376240C153209595 @default.
- W2238376240 hasConceptScore W2238376240C186413461 @default.
- W2238376240 hasConceptScore W2238376240C2779134260 @default.
- W2238376240 hasConceptScore W2238376240C2908647359 @default.
- W2238376240 hasConceptScore W2238376240C31467283 @default.
- W2238376240 hasConceptScore W2238376240C54355233 @default.
- W2238376240 hasConceptScore W2238376240C67636389 @default.
- W2238376240 hasConceptScore W2238376240C71924100 @default.
- W2238376240 hasConceptScore W2238376240C86803240 @default.
- W2238376240 hasConceptScore W2238376240C99454951 @default.
- W2238376240 hasLocation W22383762401 @default.
- W2238376240 hasOpenAccess W2238376240 @default.
- W2238376240 hasPrimaryLocation W22383762401 @default.
- W2238376240 hasRelatedWork W1899508262 @default.
- W2238376240 hasRelatedWork W1916324032 @default.
- W2238376240 hasRelatedWork W1996249630 @default.
- W2238376240 hasRelatedWork W2037645843 @default.
- W2238376240 hasRelatedWork W2039138172 @default.
- W2238376240 hasRelatedWork W2099420839 @default.
- W2238376240 hasRelatedWork W2142597850 @default.
- W2238376240 hasRelatedWork W2157372197 @default.
- W2238376240 hasRelatedWork W2228993397 @default.
- W2238376240 hasRelatedWork W2255195703 @default.
- W2238376240 hasRelatedWork W2327244157 @default.
- W2238376240 hasRelatedWork W2512979826 @default.
- W2238376240 hasRelatedWork W2570375580 @default.
- W2238376240 hasRelatedWork W2773640286 @default.
- W2238376240 hasRelatedWork W2885292374 @default.
- W2238376240 hasRelatedWork W2904415585 @default.
- W2238376240 hasRelatedWork W2920846185 @default.
- W2238376240 hasRelatedWork W2991470839 @default.
- W2238376240 hasRelatedWork W3047541683 @default.
- W2238376240 hasRelatedWork W3173386213 @default.
- W2238376240 hasVolume "38" @default.
- W2238376240 isParatext "false" @default.
- W2238376240 isRetracted "false" @default.
- W2238376240 magId "2238376240" @default.
- W2238376240 workType "article" @default.