Matches in SemOpenAlex for { <https://semopenalex.org/work/W2238389929> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2238389929 endingPage "3" @default.
- W2238389929 startingPage "BR80" @default.
- W2238389929 abstract "Transforming growth factor beta3 (TGF-beta3) has been shown to accelerate gastric ulcer healing in rats. However, little is known about the mechanism. In this study we investigated the influence of TGF-beta3 on gastric acid secretion, since gastric hyperacidity is a major cause of gastroduodenal ulcer disease.Male Sprague Dawley rats were equipped with gastric Thomas cannulas and jugular vein catheters. The acute effect of either intravenous TGF-beta3 (400 and 1200 pg/kg/h) or saline (0.15 M) on pentagastrin-stimulated (10 pg/kg/h) gastric acid secretion was evaluated by gastric acid back-titration after 5 days of recovery. Additionally, pentagastrin-stimulated gastric acid secretion was assessed after 48 hours following TGF-beta3 (1200 microg/kg/h) or saline treatment.Pentagastrin significantly increased gastric acid production. TGF-beta3 significantly reduced pentagastrin-stimulated gastric acid secretion in a dose-dependent manner as early as 15 minutes after application (saline: 124.9+/-14.9 microEq H+/15 min, TGF-beta3: 97.7+/-13.1 9 microEq H+/15 min, p<0.002). Additionally, pretreatment with TGF-beta3 abolished the effect of pentagastrin on gastric acid production. This effect lasted throughout the entire recording period of 48 hours. However, baseline physiological gastric acid production was not altered by TGF-beta3.TGF-beta3 inhibits gastric acid secretion when given prior to as well as after pentagastrin treatment. This implicates both a preventive and a therapeutic role of TGF-beta3 in gastroduodenal ulcer disease." @default.
- W2238389929 created "2016-06-24" @default.
- W2238389929 creator A5032507031 @default.
- W2238389929 creator A5042247521 @default.
- W2238389929 creator A5051509734 @default.
- W2238389929 creator A5068091576 @default.
- W2238389929 creator A5072997767 @default.
- W2238389929 date "2005-03-01" @default.
- W2238389929 modified "2023-09-23" @default.
- W2238389929 title "TGF-beta3 inhibits pentagastrin-stimulated gastric acid secretion in rats." @default.
- W2238389929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15735558" @default.
- W2238389929 hasPublicationYear "2005" @default.
- W2238389929 type Work @default.
- W2238389929 sameAs 2238389929 @default.
- W2238389929 citedByCount "1" @default.
- W2238389929 crossrefType "journal-article" @default.
- W2238389929 hasAuthorship W2238389929A5032507031 @default.
- W2238389929 hasAuthorship W2238389929A5042247521 @default.
- W2238389929 hasAuthorship W2238389929A5051509734 @default.
- W2238389929 hasAuthorship W2238389929A5068091576 @default.
- W2238389929 hasAuthorship W2238389929A5072997767 @default.
- W2238389929 hasConcept C118131993 @default.
- W2238389929 hasConcept C126322002 @default.
- W2238389929 hasConcept C134018914 @default.
- W2238389929 hasConcept C2776986829 @default.
- W2238389929 hasConcept C2777397205 @default.
- W2238389929 hasConcept C2777504413 @default.
- W2238389929 hasConcept C2779377912 @default.
- W2238389929 hasConcept C2779422922 @default.
- W2238389929 hasConcept C49039625 @default.
- W2238389929 hasConcept C71924100 @default.
- W2238389929 hasConceptScore W2238389929C118131993 @default.
- W2238389929 hasConceptScore W2238389929C126322002 @default.
- W2238389929 hasConceptScore W2238389929C134018914 @default.
- W2238389929 hasConceptScore W2238389929C2776986829 @default.
- W2238389929 hasConceptScore W2238389929C2777397205 @default.
- W2238389929 hasConceptScore W2238389929C2777504413 @default.
- W2238389929 hasConceptScore W2238389929C2779377912 @default.
- W2238389929 hasConceptScore W2238389929C2779422922 @default.
- W2238389929 hasConceptScore W2238389929C49039625 @default.
- W2238389929 hasConceptScore W2238389929C71924100 @default.
- W2238389929 hasIssue "3" @default.
- W2238389929 hasLocation W22383899291 @default.
- W2238389929 hasOpenAccess W2238389929 @default.
- W2238389929 hasPrimaryLocation W22383899291 @default.
- W2238389929 hasRelatedWork W1523906943 @default.
- W2238389929 hasRelatedWork W1588324788 @default.
- W2238389929 hasRelatedWork W1999731440 @default.
- W2238389929 hasRelatedWork W2013299165 @default.
- W2238389929 hasRelatedWork W2019923433 @default.
- W2238389929 hasRelatedWork W2038731193 @default.
- W2238389929 hasRelatedWork W2063428427 @default.
- W2238389929 hasRelatedWork W2103709256 @default.
- W2238389929 hasRelatedWork W2391120815 @default.
- W2238389929 hasRelatedWork W4290358940 @default.
- W2238389929 hasVolume "11" @default.
- W2238389929 isParatext "false" @default.
- W2238389929 isRetracted "false" @default.
- W2238389929 magId "2238389929" @default.
- W2238389929 workType "article" @default.