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- W2238394920 endingPage "155" @default.
- W2238394920 startingPage "129" @default.
- W2238394920 abstract "With the discovery two decades ago that the adult brain contains neural stem cells (NSCs) capable of producing new neurons, a great deal of research has been undertaken to manipulate these cells to repair the damaged nervous system. Much progress has been made in understanding what regulates adult neural stem cell specification, proliferation and differentiation but much remains to be determined. Lessons can be learned from understanding how embryonic neural stem cells produce the exquisitely complicated organ that is the adult mammalian nervous system. This review will highlight the role of transcriptional regulation of mammalian neural stem cells during embryonic development and compare these to the adult neural stem cell/neural precursor cell (NPC) niches of the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone (SGZ) of the hippocampal dentate gyrus. Normal physiological NSC/NPC regulation will be explored, as well as their regulation and responses following neural injury and disease. Finally, transcriptional regulation of the endogenous NSC/NPCs will be compared and contrasted with embryonic stem/induced pluripotent stem (ES/iPS) cell-derived NSC/NPCs. Recapitulation of the embryonic sequence of transcriptional events in neural stem cell development into specific neuronal or glial lineages improves directed differentiation of ES/iPS cells and may be useful for activation and specification of endogenous adult neural stem cells for therapeutic purposes." @default.
- W2238394920 created "2016-06-24" @default.
- W2238394920 creator A5000062644 @default.
- W2238394920 creator A5017173659 @default.
- W2238394920 creator A5027834486 @default.
- W2238394920 creator A5041418953 @default.
- W2238394920 creator A5047967960 @default.
- W2238394920 creator A5081185604 @default.
- W2238394920 date "2013-01-01" @default.
- W2238394920 modified "2023-10-16" @default.
- W2238394920 title "Transcriptional Regulation and Specification of Neural Stem Cells" @default.
- W2238394920 cites W1530778223 @default.
- W2238394920 cites W1582955006 @default.
- W2238394920 cites W1600855242 @default.
- W2238394920 cites W1613795242 @default.
- W2238394920 cites W1657005131 @default.
- W2238394920 cites W1760682360 @default.
- W2238394920 cites W1899815911 @default.
- W2238394920 cites W1941036671 @default.
- W2238394920 cites W1942508695 @default.
- W2238394920 cites W1960757861 @default.
- W2238394920 cites W1963619510 @default.
- W2238394920 cites W1963970654 @default.
- W2238394920 cites W1964438238 @default.
- W2238394920 cites W1964700442 @default.
- W2238394920 cites W1965306647 @default.
- W2238394920 cites W1965415058 @default.
- W2238394920 cites W1965425054 @default.
- W2238394920 cites W1966820714 @default.
- W2238394920 cites W1967238041 @default.
- W2238394920 cites W1967291818 @default.
- W2238394920 cites W1967751896 @default.
- W2238394920 cites W1968406762 @default.
- W2238394920 cites W1968656579 @default.
- W2238394920 cites W1968942251 @default.
- W2238394920 cites W1970209262 @default.
- W2238394920 cites W1970697771 @default.
- W2238394920 cites W1971912541 @default.
- W2238394920 cites W1972115217 @default.
- W2238394920 cites W1972199597 @default.
- W2238394920 cites W1972431153 @default.
- W2238394920 cites W1972856118 @default.
- W2238394920 cites W1973337141 @default.
- W2238394920 cites W1973528887 @default.
- W2238394920 cites W1974374273 @default.
- W2238394920 cites W1974470246 @default.
- W2238394920 cites W1974506021 @default.
- W2238394920 cites W1975391983 @default.
- W2238394920 cites W1976610785 @default.
- W2238394920 cites W1979755285 @default.
- W2238394920 cites W1979762984 @default.
- W2238394920 cites W1980068055 @default.
- W2238394920 cites W1980246980 @default.
- W2238394920 cites W1980615545 @default.
- W2238394920 cites W1981547140 @default.
- W2238394920 cites W1982018651 @default.
- W2238394920 cites W1982312504 @default.
- W2238394920 cites W1982749387 @default.
- W2238394920 cites W1983318575 @default.
- W2238394920 cites W1984807033 @default.
- W2238394920 cites W1984889087 @default.
- W2238394920 cites W1985705162 @default.
- W2238394920 cites W1987167495 @default.
- W2238394920 cites W1987400391 @default.
- W2238394920 cites W1987723430 @default.
- W2238394920 cites W1988044590 @default.
- W2238394920 cites W1988792859 @default.
- W2238394920 cites W1990260908 @default.
- W2238394920 cites W1990343010 @default.
- W2238394920 cites W1990474842 @default.
- W2238394920 cites W1990935914 @default.
- W2238394920 cites W1990938412 @default.
- W2238394920 cites W1992187118 @default.
- W2238394920 cites W1992399590 @default.
- W2238394920 cites W1992949513 @default.
- W2238394920 cites W1993524937 @default.
- W2238394920 cites W1993888492 @default.
- W2238394920 cites W1994304920 @default.
- W2238394920 cites W1995030818 @default.
- W2238394920 cites W1995068695 @default.
- W2238394920 cites W1995095428 @default.
- W2238394920 cites W1995626795 @default.
- W2238394920 cites W1995892646 @default.
- W2238394920 cites W1996484852 @default.
- W2238394920 cites W1998224364 @default.
- W2238394920 cites W1998916286 @default.
- W2238394920 cites W2000169334 @default.
- W2238394920 cites W2001574193 @default.
- W2238394920 cites W2001675158 @default.
- W2238394920 cites W2001810970 @default.
- W2238394920 cites W2001899714 @default.
- W2238394920 cites W2003126031 @default.
- W2238394920 cites W2003421399 @default.
- W2238394920 cites W2003548070 @default.
- W2238394920 cites W2003770008 @default.
- W2238394920 cites W2003775624 @default.
- W2238394920 cites W2004908889 @default.
- W2238394920 cites W2005170478 @default.