FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2238449244> ?p ?o ?g. }

• W2238449244 abstract "The generation of insulin-producing β cells from stem cells in vitro provides a promising source of cells for cell transplantation therapy in diabetes. However, insulin-producing cells generated from human stem cells show deficiency in many functional characteristics compared with pancreatic β cells. Recent reports have shown molecular ties between the cell cycle and the differentiation mechanism of embryonic stem (ES) cells, assuming that cell fate decisions are controlled by the cell cycle machinery. Both β cells and ES cells possess unique cell cycle machinery yet with significant contrasts. In this review, we compare the cell cycle control mechanisms in both ES cells and β cells, and highlight the fundamental differences between pluripotent cells of embryonic origin and differentiated β cells. Through critical analysis of the differences of the cell cycle between these two cell types, we propose that the cell cycle of ES cells may act as a brake for β-cell regeneration. Based on these differences, we discuss the potential of modulating the cell cycle of ES cells for the large-scale generation of functionally mature β cells in vitro. Further understanding of the factors that modulate the ES cell cycle will lead to new approaches to enhance the production of functional mature insulin-producing cells, and yield a reliable system to generate bona fide β cells in vitro." @default.
• W2238449244 created "2016-06-24" @default.
• W2238449244 creator A5054129499 @default.
• W2238449244 creator A5072081466 @default.
• W2238449244 date "2016-01-13" @default.
• W2238449244 modified "2023-10-16" @default.
• W2238449244 title "The cell cycle as a brake for β-cell regeneration from embryonic stem cells" @default.
• W2238449244 cites W1483655365 @default.
• W2238449244 cites W1520222296 @default.
• W2238449244 cites W1521943995 @default.
• W2238449244 cites W1601405552 @default.
• W2238449244 cites W1768073869 @default.
• W2238449244 cites W1911808314 @default.
• W2238449244 cites W1966383348 @default.
• W2238449244 cites W1967483776 @default.
• W2238449244 cites W1967542046 @default.
• W2238449244 cites W1967844592 @default.
• W2238449244 cites W1968728409 @default.
• W2238449244 cites W1969142310 @default.
• W2238449244 cites W1969459168 @default.
• W2238449244 cites W1970515701 @default.
• W2238449244 cites W1974413328 @default.
• W2238449244 cites W1974773432 @default.
• W2238449244 cites W1976098155 @default.
• W2238449244 cites W1982990228 @default.
• W2238449244 cites W1985263934 @default.
• W2238449244 cites W1990570289 @default.
• W2238449244 cites W1993460435 @default.
• W2238449244 cites W1995809504 @default.
• W2238449244 cites W1995812738 @default.
• W2238449244 cites W1999383862 @default.
• W2238449244 cites W2006359547 @default.
• W2238449244 cites W2006405237 @default.
• W2238449244 cites W2006919788 @default.
• W2238449244 cites W2010849315 @default.
• W2238449244 cites W2014385950 @default.
• W2238449244 cites W2018186748 @default.
• W2238449244 cites W2022489847 @default.
• W2238449244 cites W2030209853 @default.
• W2238449244 cites W2041739600 @default.
• W2238449244 cites W2044403064 @default.
• W2238449244 cites W2044939573 @default.
• W2238449244 cites W2047046198 @default.
• W2238449244 cites W2050185190 @default.
• W2238449244 cites W2054361177 @default.
• W2238449244 cites W2055001415 @default.
• W2238449244 cites W2055156816 @default.
• W2238449244 cites W2056022475 @default.
• W2238449244 cites W2057774967 @default.
• W2238449244 cites W2058414986 @default.
• W2238449244 cites W2060616041 @default.
• W2238449244 cites W2061026204 @default.
• W2238449244 cites W2063625208 @default.
• W2238449244 cites W2074742085 @default.
• W2238449244 cites W2076770967 @default.
• W2238449244 cites W2081234129 @default.
• W2238449244 cites W2081620485 @default.
• W2238449244 cites W2081783653 @default.
• W2238449244 cites W2084762332 @default.
• W2238449244 cites W2086107112 @default.
• W2238449244 cites W2087110723 @default.
• W2238449244 cites W2106219965 @default.
• W2238449244 cites W2107575419 @default.
• W2238449244 cites W2111365775 @default.
• W2238449244 cites W2111404063 @default.
• W2238449244 cites W2112156060 @default.
• W2238449244 cites W2116429223 @default.
• W2238449244 cites W2117004196 @default.
• W2238449244 cites W2121510721 @default.
• W2238449244 cites W2122986552 @default.
• W2238449244 cites W2123592823 @default.
• W2238449244 cites W2125928172 @default.
• W2238449244 cites W2126376889 @default.
• W2238449244 cites W2132408182 @default.
• W2238449244 cites W2133039575 @default.
• W2238449244 cites W2140923392 @default.
• W2238449244 cites W2142046859 @default.
• W2238449244 cites W2142744987 @default.
• W2238449244 cites W2142769261 @default.
• W2238449244 cites W2144913036 @default.
• W2238449244 cites W2145639699 @default.
• W2238449244 cites W2147777351 @default.
• W2238449244 cites W2149364745 @default.
• W2238449244 cites W2149788756 @default.
• W2238449244 cites W2152528416 @default.
• W2238449244 cites W2155609574 @default.
• W2238449244 cites W2156555850 @default.
• W2238449244 cites W2156935469 @default.
• W2238449244 cites W2157261527 @default.
• W2238449244 cites W2162560823 @default.
• W2238449244 cites W2164528882 @default.
• W2238449244 cites W2167102345 @default.
• W2238449244 cites W2172207274 @default.
• W2238449244 cites W2325068802 @default.
• W2238449244 cites W2395959362 @default.
• W2238449244 cites W2638561866 @default.
• W2238449244 cites W4238403033 @default.
• W2238449244 doi "https://doi.org/10.1186/s13287-015-0274-z" @default.
• W2238449244 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4711007" @default.
• W2238449244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26759123" @default.

• next